阿立哌唑合并舍曲林治疗以阴性症状为主的精神分裂症的研究

目的探讨阿立哌唑合并舍曲林治疗以阴性症状为主要表现的精神分裂症的疗效和安全性。方法60例患者随机分为研究组（阿立派唑＋舍曲林）和对照组（阿立派唑）各30例。两组都用阿立派唑（20—30）mg／d，研究组加用舍曲林C50～100）mg／d，治疗12周。用阴性症状量表（SANS）评定疗效，用副反应量表（TESS）评定不良反应。结果研究组比对照组早起效4周（P〈0．05），且有效率高（P〈0．01）；两组副作用无显著性差异（P〉0．05）。结论阿立哌唑合并舍曲林治疗精神分裂症阴性症状起效早，疗效好。

Combination of Aripiprazole with Sertraline in Treatment of Schizophrenia with Predominantly Negative Symptoms

Objective To explore the curative effect and safety of aripiprazole combined with sertraline in the treatment of schizophrenia with predominantly negative symptoms. Methods Sixty cases of schizophrenia with predominantly negative symptoms were randomly divided into the study group to which aripiprazole plus sertraline was given and the control group to which aripiprazole alone was given,with 30 cases in each group. The treatment course was 12 weeks. The curative effect and side effects were evaluated with t...