| 巢式PCR筛查早产儿TORCH病原感染的研究 |
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| 引用本文： | 程宁,周智辉,何莉,董莉,白亚娜.巢式PCR筛查早产儿TORCH病原感染的研究[J].中国病原生物学杂志,2010(10). |
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| 作者姓名： | 程宁 周智辉 何莉 董莉 白亚娜 |
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| 作者单位： | 兰州大学生殖健康与出生缺陷研究中心;甘肃省妇幼保健院;兰州大学公共卫生学院流行病与卫生统计研究所; |
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| 基金项目： | 国家自然科学基金资助项目(No.30571604) |
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| 摘 要： | 目的了解早产儿巨细胞病毒(HCMV)、弓形虫(TOX)、乙肝病毒(HBV)、单纯疱疹病毒1型(HSV-1)、单纯疱疹病毒2型(HSV-2)、风疹病毒(RV)与柯萨奇病毒B组3型(CVB3)的感染状况。方法采用巢式PCR对122例早产儿和75例正常新生儿进行7种病原体核酸的筛查检测。结果早产儿HCMV感染率为63.9%、TOX感染率为3.3%,HBV感染率为9.8%,HSV-1感染率为4.9%,HSV-2感染率为6.6%,RV感染率为3.3%,CVB3感染率为23.8%。早产儿HCMV、HBV、HSV-2和CVB3感染率与正常新生儿HCMV、HBV、HSV-2、CVB3感染率29.3%、1.3%、0和0比较,差异有统计学意义(P0.05)。结论 HCMV、HBV、HSV-2和CVB3感染是早产儿发生的危险因素之一。
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| 关 键 词： | 早产儿 病原 感染率 巢式PCR |
Screening for infection of TORCH pathogens in preemies using nested PCR |
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| CHENG Ning,ZHOU Zhi-hui,HE Li,DONG Li,BAI Ya-na.Screening for infection of TORCH pathogens in preemies using nested PCR[J].Journal of Pathogen Biology,2010(10). |
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| Authors: | CHENG Ning ZHOU Zhi-hui HE Li DONG Li BAI Ya-na |
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| Institution: | CHENG Ning1,ZHOU Zhi-hui1,HE Li2,DONG Li1,BAI Ya-na3 (1.Center of Reproductive Health and Birth Defects,Lanzhou University,Lanzhou,730000,China,2.Maternal and Child Health Care Hospital of Gansu Province,730050,3.Institute of Epidemiology and Statistics,Medical School,Gansu,China 730000) |
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| Abstract: | Objective To determine the state of HCMV,TOX,HBV,HSV-1,HSV-2,RV,and CVB3 infection in premature infants.Methods Nested PCR was used to examine the nucleic acids of seven kinds of pathogens in 122 premature infants and 75 normal newborns.Results The infection rates of HCMV,TOX,HBV,HSV-1,HSV-2,RV,and CVB3 in premature infants were respectively 63.9%,3.3%,9.8%,4.9%,2 6.6%,3.3%,and 23.8%.The infection rates of HCMV,HBV,HSV-2,and CVB3 in premature infants were significantly higher than 29.3%,1.3%,0%,and 0% of no... |
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| Keywords: | Premature infant(preemie) TORCH pathogens infection rate nested PCR |
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