Effect of camphor/cyclodextrin complexation on the stability of O/W/O multiple emulsions |
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Authors: | Yu Shan-Chen Bochot Amélie Bas Geneviève Le Chéron Monique Mahuteau Jacqueline Grossiord Jean-Louis Seiller Monique Duchêne Dominique |
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Institution: | UMR CNRS 8612, Faculté de Pharmacie, Université Paris-Sud, 5 rue JB Clément, 92296 Cédex, Chatenay-Malabry, France. |
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Abstract: | Camphor (CA) encapsulation in oil/water/oil multiple emulsions prepared with cyclodextrin disturbs the emulsifier potential of alpha- and beta-natural cyclodextrins (CD). It was suggested that the size and geometrical fit between the CD cavity and CA could induce CD/CA complex formation in place of emulsifier formation leading to perturbation of emulsion stability. The complexation between CA and alpha-, beta- or gamma-CD in solution in the presence of oil phase are confirmed by phase-solubility diagrams, circular dichroism and 1H NMR. Furthermore, in order to mimic the emulsion system, CD/CA/soybean oil ternary dispersions were prepared to observe the complexation behavior of alpha-, beta- or gamma-CD/CA by circular dichroism. X-ray diffraction on emulsion samples prepared with alpha- and beta-CD confirms that the precipitates observed in emulsions are probably composed of crystals of CD/CA complexes. A preliminary study of the interaction between drug and CD before the formulation seems indispensable to prevent the risk of incompatibility. |
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