2型糖尿病合并非酒精性脂肪性肝病与代谢综合征的关系

目的分析2型糖尿病（type 2 diabetes mellitus,T2DM）合并非酒精性脂肪性肝病（non-alcoholic fatty liver disease,NAFLD）的代谢特点,探讨其与代谢综合征（metabolic syndrome,MS）及各组分的关系。方法160例T2DM患者分为2组,T2DMN组为T2DM合并NAFLD,84例;T2DM组为T2DM不伴NAFLD组,76例。通过分析2组之间病程、体重指数、血压、血脂、血糖及肝功能等指标,了解T2DM合并NAFLD的临床特点,比较两组符合MS及各组分的情况。结果2组患者性别、年龄、血压、糖尿病病程无显著差异,P〉0.05;T2DMN组BMI、TG、ALT、UA显著高于T2DM组,HDL-C低于T2DM组,P〈0.01;2组之间符合MS的比较,T2DMN组符合MS的为61.90%,T2DM组42.10%,P〈0.01。结论T2DM合并NAFLD易伴发MS。T2DM是否伴NAFLD的识别对T2DM有否心血管疾病（cardiovascular disease,CVD）风险的预测具有重要意义。

The relationship between non-alcoholic fatty liver in patients with type 2 diabetes mellitus and metabolic syndrome

Objective To analyze the clinical characteristics of type 2 diabetic patients with nonalcoholic fatty liver disease （NAFLD）,and to explore the relationship between type 2 diabetes mellitus with NAFLD and metabolic syndrome and it＇s components. Methods 160 cases of type 2 diabetes patients were selected.It was divided into type 2 diabetes mellitus with non-alcoholic fatty liver disease group （T2DMN group）（n=84） and without NAFLD group （T2DM group） （n=76） according to the B-mode ultrasound. weight,blood pressure,blood lipids,glucose and liver function levels were measured respectively.The prevalence of metabolic syndrome and it associated component were compared between them.Results There were no significant difference in age,gender,and duration of type 2 diabetes between T2DMN and T2DM group （P〉0.05）;BMI,TG, ALT, LDL-C, UA were significantly higher （P〈0.01）, while HDL-C significantly lower than the control group,The difference was statistical significance （P〈0.05）. The proportion of the metabolic syndrome were respectively 61.90% and 42.10% in T2DMN group and T2DM group （P〈0.05）.Conclusion T2DM combined with NAFLD are tend to associated with MS.It is a great significance for the identification of type 2 diabetes with or without NAFLD because the appearance of it may be an indicate emergence of the risk factor of cardiovascular disease.