Influenza vaccines: Antibody responses to split virus and MF59-adjuvanted subunit virus in an adult population |
| |
Authors: | T Menegon V Baldo C Bonello D Dalla Costa A Di Tommaso R Trivello |
| |
Institution: | (1) Institute of Hygiene, University of Padua, Padua, Italy;(2) Public Health Department, Dolo Local Health District, Venice, Italy |
| |
Abstract: | The humoral immune response generated by two commercial influenza vaccines was evaluated in a randomised, double-blind trial performed in the Public Department of Dolo Health District (North-east Italy) during the winter season 1997–1998. Ninety-eight subjects were immunised with a split virus vaccine and ninety-six with a MF59-adjuvanted subunit virus vaccine (SU/MF59). The pre- and postvaccination (30 days) antibody titres were determined by hemagglutination inhibition test (HI). After immunisation protective titre rates ( 1:40) were near 100% against virus A strain and 82.5% against B strain. Both vaccines caused significant rises in geometric mean antibody titres (GMTs); however, people who received SU/MF59 vaccine were found to develop a greater immune response compared to the group immunised with SVV. According to logistic regression analysis the unprotective prevaccination immune status and the use of SU/MF59 were identified as independent factors significantly increasing the response to immunisation. |
| |
Keywords: | Adjuvant Immune response Influenza Vaccination |
本文献已被 SpringerLink 等数据库收录! |