乳痛安口服液治疗大鼠乳腺增生病实验研究

目的探讨乳痛安对大鼠乳腺增生病模型的作用效果和机制。方法 Wistar雌性未孕大鼠50只,随机分为正常对照组、模型组及低、中、高剂量乳痛安组,每组10只,用雌二醇和黄体酮诱导大鼠发生乳腺增生病,用乳痛安进行灌胃,测量大鼠第2对乳头直径,观察乳腺组织结构,测定血液中生殖激素水平。结果中、高剂量乳痛安组与模型组大鼠比较血液中的催乳素、促卵泡激素和雌二醇的浓度明显降低（P〈0.05）,黄体生成素和孕酮则明显升高（P〈0.05）,大鼠第2对乳头直径明显减小（P〈0.05）,腺泡和腺管数目减少,体积缩小（P〈0.01）。结论乳痛安通过调整大鼠体内的激素分泌水平,减弱雌激素和孕激素在乳腺的生物学效应,从而使增生的乳腺恢复正常。

Effects of Rutongan solution on hyperplasia of mammary glands in rats

Objective：To discuss the effects and mechanism of Rutongan solution on hyperplasia of mammary glands in rats.Methods： Fifty female Wistar rats without pregnancy were randomly divided into normal group,model group,low dosage group,middle dosage group and high dosage group（n=10）.Estradiol and progesterone were used to induce hyperplasia models of mammary glands in rats.The rats with hyperplasia of mammary glands were administered by gavage with Rutongan.The diameter of the second twin nipples of the rats was measured and the structure of the mammary gland tissue was observed.The level of hormone in blood was detected by radioimmunity.Results： Compared with model group,estradiol,prolactin,follicle stimulating hormone in middle and high dosage groups were decreased（P0.05）,and luteinizing hormone,progesterone were increased（P0.05）,and the diameter of the second twin nipples of the rats was reduced（P0.05）.Acini atrophy and gland ducts were smaller,and their volumes became small significantly（P0.01）.Conclusion： Rutongan can rectify the secretion of hormone in rats and weaken the biological effects of estrogen and progesterone on mammary glands so that the hyperplasia mammary glands can get recovery.