| 无花果叶水提物对体外培养瘢痕疙瘩成纤维细胞增殖的抑制 |
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| 引用本文： | 王涛,陶如,翟静,高永峰,周成军,刘金成.无花果叶水提物对体外培养瘢痕疙瘩成纤维细胞增殖的抑制[J].泰山医学院学报,2010,31(12):897-899. |
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| 作者姓名： | 王涛 陶如 翟静 高永峰 周成军 刘金成 |
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| 作者单位： | [1]泰山医学院,山东泰安271016 [2]山东大学第二医院,山东济南250033 [3]青岛大学医学院,山东青岛266021 |
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| 基金项目： | 山东省中医药管理局资助项目，泰山医学院青年基金资助项目 |
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| 摘 要： | 目的探讨无花果叶水提物对人瘢痕疙瘩成纤维细胞的生长抑制作用。方法用无花果叶水提物处理体外培养的人成纤维细胞后,进行细胞形态学检测,细胞增殖试验（MTT法）、氯胺T法检测无花果叶提取物对成纤维细胞胶原蛋白合成的抑制。结果无花果叶提取物处理后,成纤维细胞增殖活性降低;同时,胶原蛋白的合成受到抑制。结论无花果叶提取物对瘢痕疙瘩成纤维细胞的增殖有显著地抑制作用,并抑制其合成胶原蛋白。
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| 关 键 词： | 无花果叶 瘢痕疙瘩 成纤维细胞 增殖 |
Proliferation inhibition of fig leaf extraction on human keloid fibroblasts |
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| WANG Tao,TAO Ru,JING Zhai,GAO Yong-feng,ZHOU Cheng-jun,LIU Jin-cheng.Proliferation inhibition of fig leaf extraction on human keloid fibroblasts[J].Journal of Taishan Medical College,2010,31(12):897-899. |
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| Authors: | WANG Tao TAO Ru JING Zhai GAO Yong-feng ZHOU Cheng-jun LIU Jin-cheng |
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| Institution: | 1.Taishan Medical College,Taian 271016,China;2.NO.2 Hospital of Shandong Unversity,Jinan 250033,China;3.Medical College,Qingdao University,Qingdao 266021,China) |
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| Abstract: | Objective： To investigate the effect of fig leaf extraction（FLE） on the proliferation of human keloid fibroblasts.Methods： Human keloid fibroblasts were tested in vitro for FLE＇s role played in fibroblast＇s hyperplasia.Fibroblasts collagen synthesis through chloramines T measure for hydroxyproline was evaluated by way of morphology,MTT penetrating test after treatment with FLE.Results： After FLE treatment,the cells proliferation was inhibited,and collagen synthesis suppressed（P0.05）.Conclusion： The findings in this experimental study suggest that FLE has effect on inhibion of proliferation in human keloid fibrolasts,and collagen synthesis is inhibited. |
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| Keywords: | fig leaf human keloid fibroblasts proliferation |
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