| 热休克蛋白90在胃癌组织中表达的初步研究 |
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| 引用本文： | 王福根,高福平,魏谨,马平.热休克蛋白90在胃癌组织中表达的初步研究[J].安徽医药,2015,36(12):1457-1459. |
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| 作者姓名： | 王福根 高福平 魏谨 马平 |
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| 作者单位： | 211300 江苏省南京市高淳人民医院消化内科,211300 江苏省南京市高淳人民医院病理科,211300 江苏省南京市高淳人民医院病理科,211300 江苏省南京市高淳人民医院病理科 |
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| 基金项目： | 南京市医学科技发展项目计划资助(项目编号:YKK13220);南京市2013年第一批科技发展指导性计划项目(项目编号:2013ZD010) |
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| 摘 要： | 目的 探讨热休克蛋白90(HSP90)在胃癌组织中的表达及意义.方法 利用免疫组化87-8973二步法,检测80例胃癌及20例癌旁正常胃黏膜组织中HSP90的表达.结果 胃癌组织中HSP90的阳性率显著高于正常黏膜组织,差异有统计学意义(P<0.05).胃癌组织中HSP90的阳性率与肿瘤分化程度、侵犯深度、淋巴结有无转移及TNM分期相关(P<0.05).结论 HSP90可能在胃癌的发生、发展和淋巴结转移中发挥重要作用.
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| 关 键 词： | 胃肿瘤 热休克蛋白90 免疫组织化学 |
| 收稿时间： | 2015/4/29 0:00:00 |
| 修稿时间： | 2015/7/15 0:00:00 |
Expression and clinical significance of HSP90 in gastric carcinoma |
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| Wang Fugen,Gao Fuping,Wei Jin.Expression and clinical significance of HSP90 in gastric carcinoma[J].Anhui Medical and Pharmaceutical Journal,2015,36(12):1457-1459. |
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| Authors: | Wang Fugen Gao Fuping Wei Jin |
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| Institution: | Department of Gastroenterology, Gaochun People''s Hospital, Nanjing 211300, China |
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| Abstract: | Objective To investigate the roles of HSP90 in gastric carcinoma. Methods The expression of HSP90 was detected by 87-8973 immunohistochemical technique in 80 cases of gastric carcinoma and and their surrounding normal tissues(n=20). Results The positive percentage of HSP90 protein expression in gastric cancer was significantly higher than that in normal gastric mucosa tissues(P<0.05). The expression of HSP90 was significantly related with tumor differentiation, invasive depth, lymph node metastasis and TNM stage(P<0.05). Conclusion HSP90 may play an important role in the pathogenesis, development and lymph node metastasis of gastric carcinoma. |
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| Keywords: | Gastric neopliasms Heat-shock protein 90 Immunohistochemistry |
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