血清腹水白蛋白梯度与肝硬化食管静脉曲张程度的相关性

目的:探讨血清腹水白蛋白梯度(serum-ascites albumin gradient,SAAG)与肝硬化食管静脉曲张程度之间的相关性.方法:收集诊断明确的肝硬化合并腹水患者,根据食管静脉曲张程度分为无或轻度组、中度组和重度组,采用单因素方差分析、相关分析、构建受试者工作特征曲线(receiver operating characteristic,ROC)曲线等方法进行统计学分析.结果:共纳入43例患者,单因素方差分析显示3组之间存在显著差异(F=26.317,P<0.001),Spearman相关系数r=0.759,P<0.001,提示SAAG与食管静脉曲张具有正向相关性.构建ROC曲线得到曲线下面积为0.926,当SAAG取值为20.5g/L时是诊断中重度食管静脉曲张的最佳界值,此时敏感度为87.1%,特异度为83.3%.结论:SAAG与食管静脉曲张具有较好的相关关系,该指标对于中重度食管静脉曲张具有诊断价值.

Correlation between serumascites albumin gradient and degree of esophageal varices in patients with hepatic cirrhosis

AIM:To explore the correlation between serumascites albumin gradient(SAAG) and the degree of esophageal varices in patients with liver cirrhosis.METHODS:Cirrhotic patients with ascites were collected and divided into three groups according to the degree of esophageal varices:mild group,moderate group and severe group.Oneway ANOVA,correlation analysis and receiver operating characteristic(ROC) curve were used for statistical analysis.RESULTS:A total of 43 cirrhotic patients wereincluded in our study.One-way ANOVA indicated a significant difference in SAAG among the three groups(F = 26.317,P < 0.001).Spearman correlation analysis suggested a positive correlation between SAAG and esophageal varices(r = 0.759,P < 0.001).ROC curve analysis indicated that the area under the ROC curve was 0.926,and the best cut-off value for diagnosis of moderate and severe esophageal varices was 20.5 g/L,with a sensitivity of 87.1% and a specif icity of 83.3%.CONCLUSION:SAAG is correlated well with the degree of esophageal varices in cirrhotic patients,and this parameter has appreciable value in diagnosis of moderate and severe esophageal varices.