2004—2011年上海市卢湾区居民淋巴瘤的发病率及死亡率分析

目的：明确上海市卢湾区2004~2011年间淋巴瘤的发病率和死亡率。 方法：系统整理2004年1月至2011年12月上海市肿瘤登记报告中卢湾区户籍人群淋巴瘤发病和死亡资料并进行统计分析，计算淋巴瘤发病率及死亡率，并用2000年全国第5次人口普查的标准人口年龄构成进行标化。对发病率和死亡率进行趋势分析。结果： 2004-2011年间上海市卢湾区共报告淋巴瘤新发病例319例，占同期全区恶性肿瘤的3.06％。其中霍奇金淋巴瘤（Hodgkin lymphoma, HL）10例、非霍奇金淋巴瘤（Non-Hodgkin lymphoma, NHL）245例、多发性骨髓瘤（multiple myeloma, MM）64例。HL、NHL、MM的男性粗发病率分别为0.32／10万、10.90／10万、2.67／10万，女性粗发病率分别为0.47／10万、8.69／10万、2.45／10万。标化后，HL、NHL、MM的男性标化发病率分别为0.19／10万、5.43／10万、1.28／10万，女性标化发病率分别为0.34／10万、4.33／10万、0.89／10万。8年间死亡病例共200例，其中HL2例、NHL148例、MM50例。男性HL、NHL、MM平均粗死亡率分别为0.08／10万、7.19／10万、2.02／10万，女性HL、NHL、MM平均粗死亡率为0.08／10万、4.66／10万、1.97／10万。标化后，男性HL、NHL、MM的标化死亡率分别为0.03／10万、3.50／10万、0.93／10万；女性标化死亡率分别为0.01／10万、2.22／10万、0.66／10万。HL的发病和死亡率均极低；NHL的发病和死亡在50岁之后显著上升，随年龄增加而增加；MM的发病和死亡则集中在45岁之后。2004-2011年淋巴瘤发病率有一定波动，但变化趋势不大。8年间标化死亡率呈一定的上升趋势。结论：2004-2011年间上海市卢湾区户籍人群淋巴瘤发病率和死亡率高于同期我国城市人口发病率和死亡率。应积极寻找淋巴瘤高发原因，加强相应的防治工作。

Incidence and mortality of lymopha among permanent residents in Luwan district of Shanghai during 2004-2011

Objective: To analyze the incidence and mortality of lymphoma among permanent residents in Luwan district of Shanghai from January 2004 to December 2011. Methods: The data of lymphoma in permanent residents of Luwan district were collected from the database of cancer registration and management system in Shanghai. The incidence and mortality of lymphoma were calculated. The rates were standardized by the demographic composition developed in the Fifth Nationwide Census in the year 2000. The temporal trend in of the lymphoma incidence and mortality of lymphoma was assessed. Results: A total of 319 cases of lymphoma were diagnosed from January 2004 to December 2011, accounting for 3.06% of the total patients with malignant diseases. Of those cases, 10 were Hodgkin lymphoma (NHNL), 245 were non-Hodgkin lymphoma (NHL), and 64 were multiple myeloma (MM). A total of 200 cases died of lymphoma during this period, including 2 cases of Hodgkin lymphoma, 245 cases of non-Hodgkin lymphoma, and 64 cases of multiple myeloma. The crude incidence of NL, HL, and MM among males were 0.32/105, 10.90/105 and 2.67/105 respectively; and 0.47/105, 8.69/105 and 2.45/105 respectively among females. Age-standardized incidence rates were 0.19/105, 5.43/105 and 1.28/105 respectively among males; and 0.34/105, 4.33/105 and 0.89/105 respectively among females. A total of 200 cases died of lymphoma during the 8 year period, including 2 deaths from HL, 148 deaths from NHL, and 50 deaths from MM. The crude mortality rates among males were 0.08/105, 7.19/105 and 2.02/105 respectively; and 0.08/105, 4.66/105 and 1.97/105 respectively among females. Age-standardized mortality rates were 0.03/105, 3.50/105 and 0.93/105 respectively among males; and 0.01/105, 2.22/105 and 0.66/105 respectively among females. Both the incidence and mortality of NL HL were very low. For NHL, both the incidence and mortality increased significantly after 50 years of age, ; while for MM, the majority of cases and deaths occurred after 45 years of age. There were some fluctuations of lymphoma incidence during 2004-2011, but not significant. Age-standardized mortality showed an increasing trend from 2004 to 2011. Conclusion: Both the incidence and mortality rates of lymphoma in Luwan district of Shanghai from 2004 to 2011 were higher compared to the rates of Chinese urban areas during the same period. It is important to identify risk factors of lymphoma, so to take effective control measures can be taken to control its rapid increase.