| 冠通活瘀胶囊对大鼠急性心肌缺血的保护作用 |
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| 引用本文： | 宋亚娟,王欣,张丹丹,王伟明,许庆瑞,张树明,张俊威.冠通活瘀胶囊对大鼠急性心肌缺血的保护作用[J].中国临床药理学与治疗学,2011,16(1):42-45. |
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| 作者姓名： | 宋亚娟 王欣 张丹丹 王伟明 许庆瑞 张树明 张俊威 |
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| 作者单位： | 黑龙江省中医研究院中药所药理室,哈尔滨,150036,黑龙江 |
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| 摘 要： | 目的:观察冠通活瘀胶囊对小鼠注射异丙肾上腺素(ISO)后耐缺氧存活时间和注射垂体后叶素(Pit)所致的心肌缺血的影响。方法:采用腹腔注射ISO后观察小鼠耐缺氧存活时间和尾静脉注射Pit致大鼠急性心肌缺血模型,观察各给药组在腹腔注射ISO后耐缺氧存活时间和注射Pit后不同时间点Ⅱ导心电图T波变化百分率,心率变化及对血清肌酸激酶(CK)、乳酸脱氢酶(LDH)和谷草转氨酶(AST)的影响。结果:冠通活瘀胶囊低、中剂量组与模型组比较,均能明显延长小鼠耐缺氧存活时间和降低心肌缺血大鼠心电图T波峰值变化百分率(P<0.05);与注射Pit前比较,能对抗Pit致心率减慢的损伤,并能显著降低血清中CK、LDH和AST的含量。结论:冠通活瘀胶囊具有降低小鼠心肌耗氧量和抗Pit引起的大鼠急性心肌缺血作用。
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| 关 键 词： | 冠通活瘀胶囊 垂体后叶素 心肌缺血 心电图 耐缺氧 |
Protective efficacy of Guanxinhuoyu Capsule in rats with acute myocardium ischemia |
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| SONG Ya-juan,WANG Xin,ZHANG Dan-dan,WANG Wei-ming,XU Qing-rui,ZHANG Shu-ming,ZHANG Jun-wei.Protective efficacy of Guanxinhuoyu Capsule in rats with acute myocardium ischemia[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(1):42-45. |
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| Authors: | SONG Ya-juan WANG Xin ZHANG Dan-dan WANG Wei-ming XU Qing-rui ZHANG Shu-ming ZHANG Jun-wei |
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| Institution: | SONG Ya-juan,WANG Xin,ZHANG Dan-dan,WANG Wei-ming,XU Qing-rui,ZHANG Shu-ming,ZHANG Jun-wei Heilongjiang Provincial Academy of Traditional Chinese Medicine,Haerbin 150036,Heilongjiang,China |
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| Abstract: | AIM : To investigate the effect of Guanxinhuoyu Capsule against hypoxia after injection of isoproterenol and in rats with acute myocardial ischemia induced by pituitary. METHODS : The anti-hypoxia model was established by injection of isoproterenol and the acute myocardium ischemia rat model was established by caudal venous injection of pituitrin.The survival time and the changes of the T wave in lead II ECG and heart rate were observed. RESULTS :Guanxinhuoyu Capsule for low and medium dose groups compare w... |
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| Keywords: | Guanxinhuoyu Capsule Pituitary Myocardial ischemia Electrocardiogram Anti-hypoxia |
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