| 不同时间给予比索洛尔对非杓型原发性高血压患者肾素-血管紧张素-醛固酮系统的影响 |
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| 引用本文： | 刘华强,闫美兴,王少华,孙晓蕾. 不同时间给予比索洛尔对非杓型原发性高血压患者肾素-血管紧张素-醛固酮系统的影响[J]. 中国临床药理学与治疗学, 2011, 16(1): 101-104 |
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| 作者姓名： | 刘华强 闫美兴 王少华 孙晓蕾 |
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| 作者单位： | 1. 青岛市市立医院药学部,青岛,266011,山东
2. 青岛大学医学院,青岛,266021,山东 |
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| 基金项目： | 山东省卫生厅立项课题(2007hw005) |
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| 摘 要： | 目的:探讨不同时间给予比索洛尔对非杓型原发性高血压患者肾素-血管紧张素-醛固酮系统(RAAS)的影响。方法:选择非杓型原发性高血压病患者60例,采取随机平行对照试验,观察比索洛尔每日早晨(8?00)给药2.5～10 mg、比索洛尔每日夜间(20?00)给药2.5～10 mg治疗8周前后分别检测血浆肾素(Ren)、血管紧张素Ⅱ(AngⅡ)、醛固酮(Ald)浓度并进行分析评价。结果:治疗后上述各指标较治疗前均明显降低,差异有统计学意义(P<0.05)。两组间比较肾素指标无统计学差异(P>0.05),血管紧张素Ⅱ、醛固酮指标有统计学差异(P<0.05)。结论:早晨或夜间服用比索洛尔均能降低患者肾素、血管紧张素Ⅱ和醛固酮浓度,晚上服用比索洛尔对血管紧张素Ⅱ和醛固酮的影响更为显著。
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| 关 键 词： | 比索洛尔 非杓型高血压 肾素-血管紧张素-醛固酮系统 |
Effects of bisoprolol with different drug administration time on the renin-angiotension-aldosterone system of non-dippers hypertension |
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| LIU Hua-qiang,YAN Mei-xing,WANG Shao-hua,SUN Xiao-lei. Effects of bisoprolol with different drug administration time on the renin-angiotension-aldosterone system of non-dippers hypertension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(1): 101-104 |
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| Authors: | LIU Hua-qiang YAN Mei-xing WANG Shao-hua SUN Xiao-lei |
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| Affiliation: | LIU Hua-qiang 1,YAN Mei-xing 1,WANG Shao-hua 1,SUN Xiao-lei 21Department of Pharmacy,Qingdao Municipal Hospital,Qingdao 266011,Shandong,China,2 Qingdao University Medical College |
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| Abstract: | AIM : To explore effect of renin-angiotension-aldosterone system induced by bisoprolol with different time drug administration in patients with non-dipper hypertension. METHODS : The patients were randomly divided into two parallel groups.All patients were treated with bisoprolol.The first group were received bisoprolol at eight o'clock once-daily between 2.5 mg and 10 mg.The second group were received bisoprolol at twenty o'clock once-daily between 2.5 mg and 10 mg.The concentration of rennin,angiotension ... |
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| Keywords: | Bisoprolol Non-dippers hypertension Renin-angiotension-aldosterone system |
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