153Sm-EDTMP治疗骨转移癌疼痛的临床应用

目的 探讨钐－乙二胺四甲撑膦酸（^153Sm-EDTMP)治疗骨转移癌疼痛的临床疗效。方法 应用^153Sm-EDTMP治疗82例骨转移癌疼痛患者，根据治疗后疼痛缓解和生活质量的情况判断疗效，同时比较其病灶摄取放射性的变化。结果 治疗后疼痛缓解有效率为74．4％（61／82），其中显效22例（26．8％），有效39例（47．6％），稳定21例（25．6％）。治疗前列腺癌骨转移、乳腺癌骨转移、肺癌骨转移疼痛的有效率分别为80．6％（25／31）、78．9％（15／19）、63．2％（12／19）。结论 应用^153Sm-EDTMP治疗骨转移癌疼痛是1种有效的姑息治疗技术，尤其对前列腺癌和乳腺癌的骨转移疼痛疗效较好，但要注意骨髓抑制。

Clinical Effect of 153Sm-EDTMP on Bone Transfer Pain

Objective To assess the clinical effect of 153 Sm EDTMP on bone transfer pain.Methods 82 patients with bone transfer pain were treated with 153 Sm EDTMP.According to relief of the pain and promotion of the living quality after treatment,the value of the treatment was assessed.At the same time we compared the radioactive variations observed in the different focuses.Results Pain relief rate was 74.4%(61/82),including marked relief,22 cases(26.8%);effective,39 cases (47.6%);stable 21 cases (25.6%) .Effective rate in prostate carcinoma with bone transfer pain was 80.6%(25/31);in breast cancer,78.9%(15/19);in lung cancer,63.2%(12/19).Conclusion Therapy of bone transfer pain with 153 Sm EDTMP is an effective palliate treatment procedure,especially for the patients with prostate cancer or breast cancer.But we must pay attention to the possibility of bone marrow suppression.