TNF-a及IL-6对类风湿关节炎并发糖代谢异常相关研究

目的探讨类风湿关节炎（RA）并发糖代谢异常与细胞因子IL-6及TNF—a之间的相关性。方法选取类风湿关节炎并发糖代谢异常患者30例、单纯RA患者40例、TzDM患者30例及健康对照组30例，采用酶联免疫吸附法测定血清中IL-6及TNF—a水平．采用SPSS20．0软件进行统计学分析。结果RA并发糖代谢异常组血清中IL-6、TNF-a水平明显高于单纯RA组（P〈0．01、P〈0．01），RA患者血清IL-6、TNF—a水平与DAS28疾病活动度评分呈正相关（r值分别为0．63、0．59，P均〈0．01）．RA患者的HOMA—IR值与DAS28疾病活动度评分呈正相关（r=0．55，P〈0．01）。结论RA患者血清中IL-6及TNF-a的水平明显升高、且与糖代谢异常的发生密切相关，并且IL-6及TNF—a与RA患者的疾病活动度呈正相关。

Study of TNF-a and IL-6 in rhrumatoid althritis supervene with alnormal glucose metabolism.

Objective To explore the correlation of cytokines such as IL-6 and TNF-a in the rheumatoid althritis （RA） supervene with alnormal glucose metabolism. Methods Select 30 RA patients supervene with impaired glucose metabolism,40 merely RA patients without other diseases ,30 Type 2 Diabetes （T2DM）and 30 health control group. Each of them adopt ELISA to test serum level of IL-6 and TNF-a. Results The serum level of IL-6 and TNF-a in the RA supervene with Alnormal glucose metabolism group are significantly higer than merely RA group （P〈0.01 ,P〈0.01.respectively）, Meanwhile,in the RA patients, serum level of IL-6 and TNF-a were positively correlated with DAS28 （r=0.63,r=0.59,respectively,P〈0.01）, also, HOMA-IR was significantly positively correlated with DAS28 （ r=0.55 ,P〈0.01）. Conclusion The serum level of IL-6 and TNF-a in the RA patients are obviously and closely related to the happening of alnormal glucose metabolism, and were positively correlated with RA disease activity.