非酒精性脂肪肝与2型糖尿病肾损伤关系的研究

目的探讨非酒精性脂肪肝（NAFLD）与2糖尿病肾损伤发生风险之间的关系。方法T2DM患者466例，分为T2DM伴NAFLD组（N组，n=266）及T2DM不伴NAFLD组（NN组，n=200），测定24h尿微量白蛋白排泄率（UAER），比较两组间肾脏损伤发生率。结果N组BMI、DBP、FPG、FCP、FINS、HbAlC、HOMA—IR、TC、TG、ALT、UAER高于NN组（P〈0．05）；N组的肾损伤发生率高于NN组（P〈0．05）；Logistic回归分析显示，NAFLD是2糖尿病肾损伤的独立危险因素（P〈0．05）。结论N组2糖尿病肾损伤的发生率高于NN组，NAFLD是2糖尿病肾损伤的独立危险因素。

Associations between nonalcoholic fatty liver disease and renal injury in patients with type 2 diabetes

Objective To investigate the associations between non -alcoholic fatty liver disease（NAFLD） and renal in- jury in a cohort of type 2 diabetic individuals. Methods Four hundred and sixty - six patients were investigated respec- tively. Prevalences of renal injury in patients with type 2 diabetes were assessed in 466 type 2 diabetic patients, who were divided into two groups by the presence of NAFLD. T2DM with NAFLD group （ N group, n = 266） and T2DM without NAFLD group （NN group, n = 200）. The incidence of renal damage in patients with type 2 diabetes was assessed by tes- ting the 24h urinary albumin excretion rate（UAER）. Results Compared with diabetic patients without NAFLD ,the pa- tients with NAFLD had significantly higher BMI, DBP, FPG, FCP, FINS, HbA1 c, HOMA - IR., TC, TG, ALT, UAER （ P 〈 0. 05 ）. N group patients had remarkably higher renal injury prevalence than their counterparts NN group （P 〈 0. 05 ）. In multivariate logistic regression analysis, NAFLD was independently associated with prevalent of renal injury in patients with type 2 diabetes （P 〈 0. 05 ）. These associations were independent of SBP, DBP, TC, TG, HDL - C. Conclusion The incidences of renal injury in patients with type 2 diabetes were significantly higher in the patients with NAFLD than those without NAFLD. Our findings suggest that NAFLD is independently of several confounding factors, with a higher prevalence of renal injury in type 2 diabetic individuals.