| ~(99m)Tc-PYM的制备、动物实验及临床研究 |
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| 引用本文： | 张艳华,黄天贵,黄俊星,王吉欣,林保和,张梅颖. ~(99m)Tc-PYM的制备、动物实验及临床研究[J]. 北京大学学报(医学版), 1997, 0(2) |
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| 作者姓名： | 张艳华 黄天贵 黄俊星 王吉欣 林保和 张梅颖 |
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| 作者单位： | 北京医科大学临床肿瘤学院!100036 |
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| 摘 要： | 目的：研制适于临床肿瘤阳性显像的标记产品99mTC-PYM。方法：在原工作基础上，提高99mTc-PYM的放射性强度，并通过注射前往产品中加入维生素C，提高肿瘤对99mTc-PYM的摄取百分丰。结果：定量判断肺部恶性病灶的灵敏度、特异性和准确性分别为92％、100％和93％。结论：99mTC-PYM显像可用于肺癌诊断及分期，具有对疗效评价及预后判断的能力，该方法简便、安全，值得临床进一步推广应用。
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| 关 键 词： | 肿瘤／放射性核素显像 肿瘤标记.生物学 同位素标记 ~(99m)TC-平阳霉素 |
PREPARATION, BIODISTRIBUTION AND CLINICAL STUDY OF THE ~(99m)Tc-PINGYANGMYCIN |
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| ZHANG Yanhua, HUANG Tiangui,HUANG Junxing,WANG Jixin, LIN Baohe,ZHANG Meiying. PREPARATION, BIODISTRIBUTION AND CLINICAL STUDY OF THE ~(99m)Tc-PINGYANGMYCIN[J]. Journal of Peking University. Health sciences, 1997, 0(2) |
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| Authors: | ZHANG Yanhua HUANG Tiangui HUANG Junxing WANG Jixin LIN Baohe ZHANG Meiying |
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| Abstract: | Objective:The aim of this study is to prepare a product with high specific radio activity usedto tumor imaging. Methods:PYM was labelling with high radio activitY 99mTc. Vitamin C was added toincrease the percentage of 99mTc-PYM uptake in tumor,99mTc-PYM was tried to use for tumor scintigraphy in many nude mice bearing EAC and 104 patients for the first time. Results:Quantitatitive analysis:the overall sensitivity in detection of pulmonary malignant lesions was 92%,sepecificity 100%,accuracy93%. Conclusion: The results show that imaging using 99mTc-PYM was an excellent method for lungcancer diagnosis and can be used for tumor staging. It was potential to evaluation of treatment effect andprognosis. This method is simple,safe and suitable for clinical aplication. |
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| Keywords: | Neoplasms/radionuclide Tumor markers biological Isotope labeling 99mTc-PYM |
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