靶控输注丙泊酚及咪唑安定镇静对记忆的影响

目的 观察靶控输注丙泊酚、咪唑安定镇静对记忆的影响.方法 选择40例男性志愿者,年龄20～40岁,随机均分为4组,采用血浆靶控输注的方式,1组、3组输注丙泊酚,2组、4组输注咪唑安定,将镇静深度控制在OAA/S1级或3级,分别在清醒及达到预期镇静深度时听词汇,苏醒后使用词干补笔法和加工分离程序计算外显记忆及内隐记忆得分.结果 四组外显记忆与0比较无差异,3、4组内隐记忆大于0(P＜0.05),而1、2组内隐记忆与0比较无差异.结论 在靶控输注药物镇静时,随着镇静的加深,记忆逐渐消失,两种药物在相同镇静深度下对于记忆的影响相同.

Effect of propofol and midazolam on memory during target control infusion for sedation

Objective To study the effect of propofol and midazolam on memory during target control infusion for sedation.Methods Forty healthy male volunteers were randomly devided into 4 groups,all subjects received target controlled infusion with propofol or midazolam for sedation.Group 1 and group 3 were sedated to OAA/S 1 or OAA/S 3 respectively by propofol;group 2 and group 4 was sedated to OAA/S 1 or OAA/S 3 by midazolam.All subjects learned a list of words before sedation and at the different sedation depths predicted.After recovery the explicit and implicit memory were tested using word stem completion method and process dissociation procedure.Results Compared with 0,there was no significant difference in explicit memory among all the 4 groups.While there was significant difference in implicit memory for group 3 and 4,and there was no significant difference in implicit memory for group1 and group2.Conclusion Sedative-hypnotic drugs not only deepen sedation,but also impair memory as serum concentration increases during target infusion.Drug-induced amnesia is independent of sedation.Propofol and midazolam have the same efficacy on memory at the same sedation scale.