Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat |
| |
| Authors: | Galineau Laurent Belzung Catherine Kodas Ercem Bodard Sylvie Guilloteau Denis Chalon Sylvie |
| |
| Institution: | 1. Department of Pediatrics, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA;2. Pediatrics Division, Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI, USA;3. Department of Psychological Medicine, University of Auckland, New Zealand;4. Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA;5. Department of Psychology, The University of Tulsa, Tulsa, OK, USA;6. Family Science Department, Center on Young Adult Health and Development, University of Maryland School of Public Health, College Park, MD, USA;7. Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA;8. Miller Children''s Hospital Long Beach (MCHLB), Long Beach, CA, USA |
| |
| Abstract: | We investigated several aspects of the dopaminergic and serotonergic functions throughout brain development in rats prenatally exposed to MDMA ("ecstasy"). Pregnant rats were treated with MDMA (10 mg/kg s.c.) or saline from the 13th to the 20th day of gestation and studies were conducted on the progeny from both groups: (i) quantification of whole brain contents of DA, 5-HT and metabolites from the 14th day of embryonic life (E14) to weaning (21st day of postnatal life, P21); (ii) quantification of DA and 5-HT membrane transporters by autoradiography from E18 to adult age (P70); (iii) measurement of pharmacologically induced release of DA and 5-HT using microdialysis on adult (P70) freely moving rats; (iv) measurement of sucrose preference in adults (P70). Prenatally MDMA-exposed rats showed (i) a two-fold decrease of whole brain levels of 5-HT and 5-HIAA at P0; (ii) no effect on the DAT and SERT density; (iii) a strongly reduced pharmacologically induced release of DA and 5-HT at P70 in the striatum and hippocampus; and (iv) a significant 20% decrease in sucrose preference at P70. This study suggests that a prenatal exposure to MDMA induces transient and long-term neurochemical and behavioural modifications in dopaminergic and serotonergic functions. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
