电针对急性实验性高血压大鼠的降压效应及中枢机制探讨

实验用急性实验性高血压大鼠模型，电针“曲池”、“丰隆”穴，分别观察单独及协同的降压效应、电针对蓝斑核（ＬＣ）单位放电变化的影响及纳洛酮（Ｎａｌ）对电针降压作用的阻断作用。结果表明，单独针刺“曲池”或“丰隆”穴有显著降压作用、而两穴协同的降压作用明显优于单独针刺“曲池”或“丰隆”穴。电针“曲池”的降压作用可被静脉注射Ｎａｌ翻转。在电针“曲池”所致大鼠血压下降时，ＬＣ单位放电活动减少，提示电针对实验性高血压的降压作用与心输出量减少关系不大，与ＬＣ神经元活动抑制有关，内源性鸦片样物质的释放可能是这一降压机制的重要中间环节。

Effect of Electroacupuncture Decreasing Blood Pressure and Study on Its Central Mechanisims in Rats of Acute Experimental Hypertension

In rats of acute experimental hypertension, single and cooperative decreasing blood pressure effects of electroacupunctrure (EA) at Quchi(LI11)and Fenglong (ST 40)points, the effects of EA on unit discharges of locus coeruleus and blocking effect of naloxone on the decreasing blood pressure effect of EA were investigat ed. The results showed that single EA of single Quchi or Fenglong point could decrease significantly blood pressure. and the cooperative effect of EA at the two points in decreasing blood pressure was obviously superior to that of EA at Quchi or Fenglong point. The decreasing blood pressure effect of EA at Quchi point could be abolished by intravenous injection of naloxone. When blood pressure was reduced by EA of Quchi point, the discharge activiTy of the locus coeruleus (LC)would be decreased. It is suggested that the decreasing blood pressue effect of EA on the experimental hypertension is not very related with reduction of cardiac output,and the blood pressure falling effect of EA at Quchi point is related with the inhibition of firing activity of LC, and release of endogenous opioid substances may be an important intermediary link in the mechanism of the blood pressure falling.