Molecular epidemiology of primary human cytomegalovirus infection in pregnant women and their families |
| |
Authors: | Revello Maria Grazia Campanini Giulia Piralla Antonio Furione Milena Percivalle Elena Zavattoni Maurizio Gerna Giuseppe |
| |
Affiliation: | Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy. mg.revello@smatteo.pv.it |
| |
Abstract: | The source of human cytomegalovirus (HCMV) infection was investigated in 29 pregnant women with primary HCMV infection by comparing DNA sequences of UL146, UL144 and a portion of UL55 gene of HCMV strains circulating within each family. Thirteen families were identified in which the pregnant woman, the husband and/or a child were shedding HCMV. In three of these families, both the woman and the husband suffered from a concomitant primary HCMV infection. Phylogenetic analysis of UL146, UL144, and UL55 genes indicated that strains circulating within each family were identical, whereas strains from different families appeared to be distinct. However, identical UL146, UL144, and UL55 DNA sequences were observed sporadically among unrelated strains. A child rather than the husband was the virus source for the great majority of pregnant women. No association was observed between UL144 polymorphisms and intrauterine transmission. |
| |
Keywords: | HCMV UL146 UL144 pregnancy molecular epidemiology |
本文献已被 PubMed 等数据库收录! |
|