| CE基因多态性及其血清水平与心肌梗死的关系 |
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| 引用本文： | 崔卫华,高义,王玉敏,卢琪华.CE基因多态性及其血清水平与心肌梗死的关系[J].中国老年学杂志,2001,21(2):113-114. |
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| 作者姓名： | 崔卫华 高义 王玉敏 卢琪华 |
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| 作者单位： | 1. 白求恩国际和平医院，河北 石家庄 050082
2. 黑龙江省第二医院 |
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| 摘 要： | 目的 探讨血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性及其血清水平与老年心肌梗死的关系。方法 应用聚合酶链反应(PCR)方法检测60岁以上心肌梗死患者35例及正常对照者48例的ACE基因。结果 老年心肌梗死组ACE基因中缺失型(DD型)分布(60%)明显高于正常对照组(29.17%)(P＜0.05)，缺失型(D型)等位基因频率(74.29%)也明显高于对照组(51.05%)(P＜0.05)。DD型血清ACE水平明显高于II型(P＜0.001)。结论 ACE基因缺失型及高血清ACE水平可能是老年人心肌梗死的一个重要危险因素。
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| 关 键 词： | 血管紧张素转换酶 基因 心肌梗死 老年 |
| 文章编号： | 1005-9202(2001)02-0113-02 |
| 修稿时间： | 1999年12月7日 |
Study on relationship
between polymorphis m in gene and serum level of the angitensin converting enzyme and
elderly patients with myocardial infarction |
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| Abstract: | Objective To study the relationship between the polymorphism inthe gene insertion/deletion(I/D),the level in serum of angi otensin converting enzyme(ACE) and elderly patients with myocardial infarction(M I).Methods We determined ACE gene of 35 elderly patients wit h MI and 48 healthy subjects by the polymerized chain-reaction(PCR).Results The frequencies of DD genotype(60%) and D allele( 74.29%) were significantly higher in the MI group than those in the healthy sub j ects(29.17% and 51.05%，P＜0.05).The ACE level in serum of DD genotype is apparently higher than that of type Ⅱ(P＜0.001).Conclusions The DD genotype and the high level in serum o f ACE may be an important risk factor of MI in elderly population. |
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