麦冬水浸提液对大鼠胚胎/胎儿发育毒性研究

目的:观察麦冬水浸提液对SD大鼠胚胎/胎儿的发育毒性。方法:采用SD孕鼠,分为溶媒对照组、麦冬组,每组20只交配成功动物,于妊娠第6~17天经口灌胃给予麦冬水浸提液26.9 g.kg-1,每天1次,于妊娠第20天解剖。观察母体动物的临床症状、体重变化、黄体数、着床数、胚胎生存死亡情况、生存胎仔的体重、性别、外观、内脏及骨骼检查等指标。结果:麦冬水浸提液对SD大鼠的母体及胚胎/胎儿发育各项指标未见明显影响。结论:在本实验条件下,麦冬水浸提液未见明显的母体毒性与胚胎/胎儿发育毒性。

Effects of Radix Ophiopogonis decoction on embryo-fetal development in rats

Objective : To investigate the potential developmental toxicity of Radix Ophiopogonis decoction in SD rats. Method : Timed-pregnant SD rats were given Radix Ophiopogonis decoction (26.9 g·kg^-1) or vehicle (distilled water) by gavage on gestation days 6-17. Maternal clinical sign, abortions, premature deliveries, and body weight were monitored throughout gestation. At termination (gestation days 20) pregnant females were evaluated for clinical status and gestational outcome; live fetuses were examined for gender, external, visceral and skeletal malformation and variations. Result : No deaths, premature deliveries or dose-related clinical signs were attributed to Radix Ophiopogonis decoction. Maternal body weight and body weight gain were not affected. There were no effects on fetus weight and viability, incidences of fetal malformation and variation. Conclusion : These results demonstrated that Radix Ophiopogonis decoction had no detectable adverse effects in either the treated F₀ female rats or the fetuses.