| 中国四川北部肺癌患者谷胱苷肽硫转移酶M1基因多态性分析 |
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| 引用本文： | 马代远,杜国波,谭榜宪,柳弥,赵妍丽,杨明辉. 中国四川北部肺癌患者谷胱苷肽硫转移酶M1基因多态性分析[J]. 肿瘤研究与临床, 2011, 23(1): 251-253. DOI: 10.3760/cma.j.issn.1006-9801.2011.04.011 |
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| 作者姓名： | 马代远 杜国波 谭榜宪 柳弥 赵妍丽 杨明辉 |
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| 作者单位： | 川北医学院附属医院肿瘤科,南充,637000;川北医学院附属医院风湿免疫研究所,南充,637000; |
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| 摘 要： | Objective To analyze the genetic polymorphism of GSTM1 to lung cancer patients in north Sichuan of China and compare with race from other district.Methods PCR-based technique was used to detect the genotypes of GSTM1 in lung cancer patients.Results In local lung cancer patients,the frequency of homozygous deletions(null genotype) for GSTM1 was 58.4 % (73/125).Among the patients,the frequencys of null genotype for GSTM1 were 62.5 % (20/32) in female,56.9 % (53/93) in male,56.1% (32/57)in patients with squamous cell carcinoma and 54.8 % (17/31) in patients with adenocarcinoma,respectively.The frequency of deletions of GSTM1 in lung cancer patients from north Sichuan of China is slightly exceeding those of Europe and Americas (P ＜0.05) and similar to the domestic result (P ＞0.05).Conclusion The genetic polymorphism of GSTM1 to lung cancer patients in north Sichuan of China dosen' t show distinguished feature for this district and race.
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| 关 键 词： | 肺肿瘤 多态性,遗传 谷胱苷肽转移酶 |
Genetic polymorphism of GSTM1 to lung cancer patients in north Sichuan of China |
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| MA Dai-yuan,DU Guo-bo,TAN Bang-xian,LIU Mi,ZHAO Yan-li,YANG Ming-hui. Genetic polymorphism of GSTM1 to lung cancer patients in north Sichuan of China[J]. Cancer Research and Clinic, 2011, 23(1): 251-253. DOI: 10.3760/cma.j.issn.1006-9801.2011.04.011 |
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| Authors: | MA Dai-yuan DU Guo-bo TAN Bang-xian LIU Mi ZHAO Yan-li YANG Ming-hui |
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| Abstract: | |
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| Keywords: | Lung neoplasmsPolymorphism geneticGlutathione transferase |
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