| MPTP小鼠黑质神经元细胞凋亡及Deprenyl抗凋亡作用的研究 |
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| 引用本文： | 匡永锋 童启进. MPTP小鼠黑质神经元细胞凋亡及Deprenyl抗凋亡作用的研究[J]. 脑与神经疾病杂志, 1999, 7(3): 133-135 |
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| 作者姓名： | 匡永锋 童启进 |
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| 作者单位： | 广州医学院附属市二人民医院神经内科!510150(匡永锋)，首都医科大学附属北京友谊医院神经内科(童启进，王德新，赵伟秦) |
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| 摘 要： | 目的：观察MPTP-Parkinsonism小鼠多巴胺能神经元细胞凋亡及Deprenyl抗凋亡作用；方法：应用TUNEL染色、TH、BCL－2免疫组化染色、TUNEL／TH双标染色和电镜技术观察多巴胺能神经元凋亡及Deprenyl抗凋亡作用；结果：模型鼠脑黑质内有多巴胺能神经元凋亡．而Deprenyl可阻止这种神经元凋亡；结论：1．模型中多巴胺能神经元的丢失可能是通过细胞凋亡机制实现的；2．Deprenyl可能部分阻止多巴胺能神经元凋亡。
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| 关 键 词： | MPTP 帕金森氏病 细胞凋亡 Deprenyl BCL－2 |
The study of the apoptosis of dopaminergic neurons and the antiopoptotic effect of deprenyl in MPTP-mice |
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| Kuang Yongfeng, Tong Qijin, Wang Dexin, Zhao Weiqin. The study of the apoptosis of dopaminergic neurons and the antiopoptotic effect of deprenyl in MPTP-mice[J]. Journal of Brain and Nervous Diseases, 1999, 7(3): 133-135 |
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| Authors: | Kuang Yongfeng Tong Qijin Wang Dexin Zhao Weiqin |
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| Abstract: | Object: TO investgate the apoptosis of dopaminergic neurons and the antiopoptotic effect of deprenyl in MPTP-Parkinsonia mice; Method: To examine the apoptosis of dopaminergic neurons and the antiopoptotic effect of deprenyl by using TH and BCL-2 stains, TUNEL stain and TUNEL/TH double stainings. Result: There are apoptosis of dopaminergic nuerons, and deprenyl can prevent apoptosis of dopaminergic neurons in the MPTP-Parkinsonial mice. Conclusion: 1. The loss of nigral dopaminergic neurons may occur via active apoptotic mechanism in MPTP-Parkinsonian mice. 2. Deprenyl can prevent apoptosis of dopaminergic neurons in MPTP-Parkinsonian mice. |
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| Keywords: | MPTP Parkinsinism Apoptosis Deprenyl BCL-2 |
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