丁咯地尔对大鼠坐骨神经损害的保护作用

目的观察丁咯地尔对坐骨神经损害后恢复的影响。方法SD大鼠100只随机分为正常组、模型组、甲钴胺组(阳性对照组,104μg·kg~(-1))、丁咯地尔组(40 mg·kg~(-1))。以大鼠坐骨神经挤压伤建立动物模型,以坐骨神经传导速度、坐骨神经干病理切片(光镜、电镜)为观察指标,考察丁咯地尔对坐骨神经损害后恢复的影响。结果wk 4时甲钴胺组和丁咯地尔组均能显著增加坐骨神经传导速度,甲钴胺组与模型组比较有显著差异(P<0.05),丁咯地尔组与模型组比较有非常显著差异(P<0.01);4 wk时丁咯地尔组和甲钴胺组髓鞘形态结构接近正常,而模型组神经髓鞘溃变程度很高。结论丁咯地尔对坐骨神经损害有确切的修复作用。

Protective effects of buflomedil on sciatic nerve crush lesion in rats

AIM Study on protective effects of buflomedil to sciatic nerve crush lesion in rats.METHODS One hundred SD rats were randomly divided into normal group,model group,mecobalamin group (104μg·kg~(-1)), and buflomedil group (40 mg·kg~(-1)).Sciatic nerve crush lesion model were established in rats.The conduction velocity of sciatic nerve and the morphological changes were observed by light and electron microscope.RESULTS At the end of 4 weeks,the conduction velocity of buflomedil group increased obviously as well as methycobal group,with significant difference (P<0.05,P<0.01).Almost normal myelin was observed in the buflomedil group and mecobalamin group,and the severe degeneration was observed in the model group.CONCLUSION Buflomedil shows recovery effects on the sciatic nerve crush lesion.