| 乙肝妊娠患者孕早期绒毛姐妹染色单体交换率的研究 |
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| 引用本文： | 岳淑芬,宋芳,赵紫薇,郝奋. 乙肝妊娠患者孕早期绒毛姐妹染色单体交换率的研究[J]. 包头医学院学报, 2006, 22(2): 128-129 |
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| 作者姓名： | 岳淑芬 宋芳 赵紫薇 郝奋 |
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| 作者单位： | 包头医学院组胚教研室,内蒙古,包头,014010;包头医学院组胚教研室,内蒙古,包头,014010;包头医学院组胚教研室,内蒙古,包头,014010;包头医学院组胚教研室,内蒙古,包头,014010 |
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| 基金项目： | 内蒙古包头市医药卫生项目 |
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| 摘 要： | 目的:探讨乙肝患者体内遗传物质的损伤情况.方法:选择正常对照组20例,单纯HBsAg( )增高组16例,乙肝组16例,乙肝恢复组10例,HBsAg、抗HBe、抗HBc三阳组12例,脂肪肝组16例,做孕早期绒毛姐妹染色单体交换(SCE)率的检测.结果:单纯HBsAg( )增高组、乙肝组自发和诱发SCE逐步增高,且与对照组间均有显著差异;乙肝恢复组较乙肝组SCE下降;其他肝病患者较乙肝组SCE均较低.结论:乙肝妊娠妇女体内出现DNA损伤及修复功能障碍.
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| 关 键 词： | 乙肝 孕早期 绒毛 姐妹染色单体交换 |
| 文章编号： | 1006-740X（2006）02-0128-02 |
| 收稿时间： | 2005-10-21 |
| 修稿时间： | 2005-10-21 |
The Study on Chorion Sister Chrimatid Exchange (SCE) Rate of the Early Pregnant Women with Hepatitis B |
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| YUE Shufen,SANG Fang,ZHAO Ziwei,HAO Fen. The Study on Chorion Sister Chrimatid Exchange (SCE) Rate of the Early Pregnant Women with Hepatitis B[J]. Journal of Baotou Medical College, 2006, 22(2): 128-129 |
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| Authors: | YUE Shufen SANG Fang ZHAO Ziwei HAO Fen |
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| Abstract: | Objective: To investigate the damage extent of germ plasm in the patients with hepatitisB. Methods: To detect the chorion SCE rate of the control groups, including 20 normal pregnant women,Group 1 of 16 with increased HBsAg, Group 2 of 16 with hepatitisB, Group 3 of 10 with recovered hepatitis B, Group 4 of 12 with HBsAg(+), HBeAb(+), HbcAb(+) and Group 5 of 16 with fatty liver. Results: Spontaneous and induced SCE rate increased graduallyin control group, Group 1 and Group 2. At the same time, there were significantly differences among the three groups. In Group 3 and the other two groups, SCE rate all decreased. Conclusion: DNA damnification and repair obstruction appeared in the pregnant women with hepatitis B. |
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| Keywords: | Hepatitis B Early pregnant Chorion Sister chrimatid exchange(SCE) |
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