Cochlear blood flow in the rat. A methodological evaluation of the microsphere method |
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| Authors: | M Hillerdal |
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| Affiliation: | 1. Division of RI-Convergence Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea;2. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea;3. Department of Nuclear Medicine, Ewha Womans University School of Medicine, Seoul 07985, Republic of Korea;4. Department of Radiology, University of California San Francisco School of Medicine, San Francisco, CA 94143, USA;5. Center for Nanomolecular Imaging and Innovative Drug Development, Advanced Institutes of Convergence Technology, Suwon 16229, Republic of Korea;6. Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea;1. Department of Heart and Vessels, Careggi Hospital, Florence, Italy;2. Department of Experimental and Clinical Medicine, University of Florence, Italy;3. Don Carlo Gnocchi Foundation IRCCS, Florence, Italy;4. Nuclear Medicine Unit, Department of Clinical Physiopathology — University of Florence, Careggi Hospital, Florence, Italy;5. Division of Cardiology, Hospital Policlinico of Bari, Bari, Italy;6. Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Departments of Pediatrics and Pharmacology, University of Alberta, Edmonton, Alberta, Canada |
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| Abstract: | With the microsphere method it is possible to quantify the blood flow in various organs. The blood flow in the cochlea is only a very small part of the cardiac output and only relatively few microspheres are caught in this organ, which necessitates large groups of animals for such studies. The method has, however, not been fully evaluated for studies of small organs in small animals. In this study, 130 rats of various ages with normal or arterial hypertension were investigated. The blood flows of 97 animals were possible to evaluate. It was found that physiological parameters, such as PCO3, pH, PO2 and mean arterial blood pressure within the rather wide limits usually present in the anesthetized animal did not affect the cochlear blood flow to any great extent and that the method is feasible for studies of the blood flow through the inner ear in small animals. |
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