Structural gene encoding human factor XII is located at 5q33-qter |
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| Authors: | N J Royle M Nigli D Cool R T MacGillivray J L Hamerton |
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| Institution: | (1) Department of Human Genetics, University of Manitoba, Canada;(2) Department of Biochemistry, University of British Columbia, Canada;(3) Present address: Department of Genetics, University of Leicester, England |
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| Abstract: | The gene encoding human factor XII (F12 ) or Hageman factor has been mapped to 5q33-qter. This has been achieved by analyzing the results obtained from hybridizing a cloned fragment from the factor XII gene to a panel of human-hamster somatic cell hybrid DNAs and also by in situ hybridization to normal human metaphase cells. The previously reported results localizingF12 to 6p23 are discussed. |
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