2008年我院药物不良反应的分析

目的分析药物不良反应（ADR）发生的特点与规律，促进临床合理用药。方法采用回顾性方法，对2008年1月-12月上报的118份ADR报告，按患者年龄、性别、给药途径、引起ADR的药品种类、涉及器官或系统以及临床表现等进行统计、分析。结果静脉给药较其他给药途径更易发生ADR（占69．5％）；抗感染药物引发ADR的比例最高（占47．5％），其次为神经系统与心血管系统药物；氟喹诺酮类是引发ADR的主要抗菌药物（19例，占33．9％），其中又以左氧氟沙星为首。ADR的临床表现以皮疹、瘙痒等皮肤及附件损害为主，其次为消化系统以及循环系统损害。结论应强化ADR监测意识，完善相关报告分析制度，确保临床安全、有效、合理用药。

Annual reports:analysis of ADR in Shizuishan hospital in 2008

Objective To analyze the characterstics and regularity of the adverse drug resction(ADR) occurred in our hospital so as to promote rational drug use.Methods By a retrospective study,a total of 118 ADR case reports collected from our hospital from Jan.to Dec.in 2008 were subjected to a statistical analysis in respect of patients' age and sex.Results Of the total 118ADR case reports,69.5% were induced by intravenous administration and 47.5%were induced by anti-infective drugs,followed by drugs used for nervou...