原发性高血压合并代谢综合征患者血清游离脂肪酸水平与颈动脉内中膜增厚关系的研究

目的 探讨原发性高血压(EH)合并代谢综合征(MS)患者游离脂肪酸(FFA)水平与颈动脉内中膜厚度(IMT)的关系.方法 选择EH合并MS患者69例(EH+MS组)、单纯EH患者57例(EH组).选取健康体检者50名作为健康对照组.比较3组患者FFA、体重指数(BMI)、颈动脉IMT及颈动脉内中膜增厚发生率情况.结果 ①EH+MS组的BMI、甘油三酯(TG)、空腹血糖(FPG)均高于单纯EH组和健康对照组[(26.0±2.1)、(24.9±2.3)、(23.6±1.6)kg/m2,(2.40±0.81)、(1.93±0.55)、(1.49±0.36)mmol/L,(5.64±0.82)、(5.10±1.08)、(4.70±0.90)mmol/L,F值分别为20.06、30.96、15.17,P＜0.05或＜0.01].②EH+MS组血清FFA高于单纯EH组及健康对照组[(562.11±55.12)、(402.65±49.53)、(356.23±45.93)μmol/L,F=277.28,P＜0.01].③3组颈动脉IMT依次为(1.10±0.13)、(0.82±0.12)、(0.70±0.11)mm,两两比较差异均有统计学意义(P均＜0.01);颈动脉IMT增厚发生率依次为28.99%(20/69)、17.54%(10/57)、2.00%(1/50),两两比较差异均有统计学意义(P均＜0.01).结论 EH合并MS患者血中FFA水平升高与颈动脉内中膜增厚相关.

Association between intima-media thickness and free fatty acids in essential hypertensive patients with metabolic syndrome

Objective To investigate the association between intima-media thickness (IMT) and free fatty acids (FFA) in hypertensive patients with metabolic syndrome (MS). Methods IMT, FFA and body mass index (BMI) were measured in 69 hypertensive patients with metabolic syndrome (MS group) ,57 hypertensive patients without metabolic syndrome ( Non-MS group) ,and 50 healthy controls ( NC group). Results In the MS group,The BMI, serum levels of triglyceride (TG), fasting blood glucose (FPG) and FFA were ( 26.0 ± 2.1 ) kg/m2, (24.0 ±0.81 ) mmol/L and (5.64 ± 0.82) mmol/L respectively, which were significantly higher than those in the Non-MS group ( (24.9 ± 2.3 ) kg/m2, ( 1.93 ± 0. 55 ) mmol/L and ( 5.10 ± 1.08 ) mmol/L respectively ) and the NC group ( (23.6 ± 1.6), ( 1.49 ± 0.36) mmol/L and (4.70 ± 0.90) mmol/L respectively) ( F = 20.06, 30.96 and 15.17,P ＜0.05 or 0.01 ). FFA in the MS group ((562.11 ± 55.12)μmol/L) were significantly higher than that in the Non-MS group (402.65 ± 49.53 ) μmol/L) and the NC group ( ( 356.23 ± 45.93 ) μmol/L) ( F = 277.28, P ＜0. 01 ). IMT in the MS group, Non-MS group and NC group were (1. 10 ± 0. 13 )mm, (0. 82 ± 0. 12 )mm and (0.70 ± 0.11 ) mm, respectively, with significantly difference ( P ＜ 0. 01 ). In addition, the incidence of thickening was 28.99% (20/69), 17.54% ( 10/57 ) and 2.00% ( 1/50 ), respectively, with significantly difference ( P ＜0.01 ). Conclusions Serum level of FFA is associated with IMT in hypertensive patients with metabolic syndrome.