Effect of various oxygen concentrations on the ATP content in isolated hepatocytes of rats adapted and nonadapted to hypoxia |
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Authors: | L D Luk'yanova A M Dudchenko V V Belousova |
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Institution: | (1) Laboratory of Bioenergetics, Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow |
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Abstract: | It is shown that isolated hepatocytes are capable of perceiving slight changes in the envioronmental oxygen concentration.
A complicated phase dependence exists between adenosine triphosphate and partial oxygen pressure, which differs in cells from
animals with high and low resistance to hypoxia, the former showing a more stable and resistant energy-synthesizing function
than the latter. After long-term adaptation to periodic hypoxia, the resistance of the energy-synthesizing function rises
in hepatocytes from high-resistant animals, and falls in low-resistant animals suggesting a fundamentally different organization
of the emergency compensatory mechanisms of the energy-synthesizing function in hepatocytes of animals of these two types.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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12, pp. 576–581, December, 1994 |
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Keywords: | hepatocytes hypoxia adenosine triphosphate resistance adaptation |
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