托特罗定治疗前列腺术后膀胱过度活动症20例

目的:观察经尿道前列腺切除(TUP)术后早期使用托特罗定对早期膀胱过度活动症症状的临床疗效.方法:采用随机对照单盲临床试验设计,将38例术后患者随机分为两组.试验组(20例)于手术当日起即口服托特罗定,2 mg/次,至拔除尿管后3 d停药.结果:试验组膀胱痉挛每日发作次数、持续时间、术后膀胱持续冲洗引流液转清时间、拔除尿管时间、每日排尿次数及急迫性尿失禁发作次数均低于对照组(P均＜0.01),而平均每次排尿量高于对照组(P＜0.01).试验组口干的发生率高于对照组(P＜0.01),消化不良和便秘发生率与对组照无显著差异(P＞0.05).结论:托特罗定对于预防和治疗TUP术后早期膀胱痉挛临床疗效确切,能明显改善拔管早期尿频和急迫性尿失禁症状.

Tolterodine in the Treatment of Bladder Overactivity after Prostatectomy 20 Patients

Objective:To evaluate the efficacy of tolterodine in the control of bladder spasm and micturitional symptoms of overactive bladder during the early stage after transurethral prostatectomy (TUP).Methods:A single -blind,randomized controlled trial was adopted.Thirty -eight patients who underwent TUP for symptomatic benign prostates hyperplasia were randomly divided into tolterodine group and control group.In tolterodine group patients received tolterodine(2mg twice daily)after TUP.In control group patients didn't receive tolterodine.Results:The number of bladder spasm episodes,duration of bladder spasm,the time of bladder perfusion clearance,indwelling catheter delivery in tolterodine group reduced significantly as compared with control group.After removal of catheter,the number of voids per day,mean urine volume per void,number of incontinent episodes in tolterodine group improved significantly as compared with control group.The rate of dry mouth was40%for tolterodine group,16.7%for control group.Conclusion:Tolterdine2mg twice daily is effective and well tolerated in the prevention and treatment of postoperative bladder spasm.Tolterodine could also significantly alleviate early irritative symptoms after TUP.