抑郁症、焦虑症患者事件相关电位对照研究

目的:探讨抑郁症、焦虑症患者脑诱发电位的变异特点及临床应用价值.方法:共有46例抑郁症患者(抑郁症组)、41例焦虑症患者(焦虑症组)及42名健康志愿者(正常组),使用美国Nicolet Bravo脑电生理仪进行事件相关电位P300(P300)和关联性负变化(CNV)的检测.并于治疗2个月时对两患者组进行相同项目的随访.结果:与治疗前比较,抑郁症组P300靶N2、P3潜伏期缩短(P＜0.05),靶P3波幅升高(P＜0.01),CNV潜伏期M1缩短(P＜0.01),波幅M1、M2升高(P均＜0.05).焦虑症组P300靶P3潜伏期缩短(P＜0.05),CNV波幅M1下降(P＜0.05),指令信号后负变化(PINV)的出现率下降(P＜0.05).治疗后与正常组比较,抑郁症组P300非靶P2波幅偏低(P＜0.01),P300的双峰P2波和CNV的PINV出现率均偏高(P＜0.05～0.01);焦虑症组CNV的潜伏期M2缩短(P＜0.01).抑郁症组与焦虑症组治疗后比较在P300非靶P2波幅、双峰P2波出现率,CNV潜伏期M2和PINV出现率等指标之间差异有显著性(P均＜0.01).结论:抑郁症、焦虑症患者脑诱发电位有自己的变异特点,在诊断和鉴别诊断方面有一定的价值.

Comparative study of brain evoked potentials in patients with depression or anxiety

Objective:To investigate the features and clinical application of brain evoked potentials (BEP) in patients with depression or anxiety. Method:A total of 46 patients with depression,41 patients with anxiety and 42 normal controls were involved.The event related potential P300 and CNV were recorded by Nicolet Bravo instrument.The patients were followed up with the same items after 2 months treatment. Results:In depression group,latencies of target N2/P300,target P3/P300 and M1/CNV shortened,and amplitudes of target P3/P300,non-target P2/P300,M1/CNV and M1/CNV increased after treatment(P<0.05 to 0.01). In anxiety group,latency of P3/P300 shortened(P<0.05), and amplitude of M1/CNV and rate of PINV reduced(P<0.05).Compared with the normal controls, depression group showed decreased amplitude of non-target P2/P300 and increased double peak of P2/P300 and PINV/CNV (P<0.05 to 0.01).While in the anxiety group P<0.01).There were significant difference in the amplitude of non-target P2/P300,the latency of M2/CNV,double peak of P2/P300 and the rate of PINV between depression group and anxiety group after treatment (P<0.01). Conclusion:The features of BEP in patients with depression or anxiety are diverse has some clinical application in diagnosis.