甲磺酸多拉司琼与地塞米松磷酸钠在两种输液中的配伍稳定性考察

目的：考察甲磺酸多拉司琼与地塞米松磷酸钠在两种输液中的配伍稳定性。方法：模拟临床操作，在室内室温（25℃）不避光环境下，临床常用量甲磺酸多拉司琼与地塞米松磷酸钠分别在5%葡萄糖注射液（5%GS）和0.9%氯化钠注射液（NS）中配伍，在0 h（配制后5 min内）、3、6、24 h对配伍液的物理稳定性（外观、不溶性微粒）、化学稳定性（pH值、浓度）进行考察。结果：配伍液在24 h内保持无色、澄清，未见气泡、絮状物和沉淀产生，不溶性微粒、pH值与配伍液中两药浓度变化符合配伍要求，且色谱图均未发现异常色谱峰。结论：在室内室温（25℃）不避光时，甲磺酸多拉司琼注射液和注射用地塞米松磷酸钠于100 mL 5%GS或0.9%NS中，24 h内配伍稳定。

Stability Study of Dolasetron Mesylate and Dexamethasone Sodium Phosphate Admixture in Common Infusions

Objective: To inves tigate the stability of admixture of dolasetron mesylate and dexametha-sone sodium phosphate (DSP) in common infusions. Methods: Simulating clinical practice, at ambient con-ditions (25℃), dolasetron mesylate and DSP were dissolved into 5% glucose (GS) and 0.9% sodium chlo-ride (NS), respectively. Their physical (appearance and insoluble particles) and chemical (pH and concen-traton) stability were investigated at 0 h (within 5 min after admixture), 3 h, 6 h, and 24 h. Results: The admixtures of dolasetron mesylate and DSP in common infusions remained colorless and clear. No visible bubble, floc or precipitation et al was observed. Particulate matter, pH and concentrations of the two com-ponents met the standard of stability. Conclusion: At ambient conditions (25℃), the admixtures of 100 mg dolasetron mesylate injection and 10 mg or 20 mg DSP for injection in 100 mL 5%GS or 9% NS, are stable within 24 hours.