含蓝莓花色苷的谷物发酵物抗疲劳作用研究 |
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引用本文: | 王紫玉,傅经明,孙寿丹,刘伟,庞伟,钱令嘉,蒋与刚.含蓝莓花色苷的谷物发酵物抗疲劳作用研究[J].军事医学,2016(7):558-560. |
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作者姓名: | 王紫玉 傅经明 孙寿丹 刘伟 庞伟 钱令嘉 蒋与刚 |
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作者单位: | 1. 军事医学科学院卫生学环境医学研究所,天津300050; 广西医科大学公共卫生学院,南宁 530021;2. 军事医学科学院卫生学环境医学研究所,天津,300050;3. 天津医院营养科,天津,300211;4. 军事医学科学院基础医学研究所,北京,100850 |
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基金项目: | 军队“十二五”后勤科研计划(BWS12J038) |
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摘 要: | 目的:观察含蓝莓花色苷的谷物发酵物(简称蓝禾,LH)对小鼠的抗疲劳作用。方法雄性昆明小鼠80只,分2批进行实验。(1)第1批实验:昆明小鼠随机分为对照组和低、中、高剂量LH干预3组,每组10只小鼠,其中对照组小鼠灌胃蒸馏水17.5 ml/kg体质量,LH干预组小鼠灌胃剂量分别为8.75、17.5、35.08 ml/kg体质量。连续灌胃28 d,测定小鼠负重游泳时间。(2)第2批实验:昆明小鼠随机分为对照组及高剂量LH干预组,每组20只小鼠,分别灌胃蒸馏水和LH,灌胃剂量均为35.08 ml/kg 体质量。连续灌胃28 d,测定小鼠血乳酸( LA)、血清尿素氮(BUN)和肝糖原的含量。结果与结论(1)与对照组比较,LH干预组小鼠负重游泳时间均显著延长( P<0.01),高剂量LH干预效果最好;(2)LH干预组小鼠游泳后20 min,LA含量呈下降趋势(P>0.05)、BUN含量明显降低(P<0.05)、肝糖原储备量显著增高(P<0.05)。 LH具有显著的抗疲劳作用。
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关 键 词: | 含蓝莓花色苷的谷物发酵物 抗疲劳 小鼠 |
Anti-fatigue activity of fermented grain-containing blueberry anthocyanins |
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Abstract: | Objective To investigate the anti-fatigue activity of fermented grain-containing blueberry anthocyanins ( LANHE,LH) in mice.Methods Experiments were conducted in two phases .In the first phase , forty mice were randomly divided into four groups:control group(distilled water,dw) and three LH administration groups (8.75,17.5 and 35.08 ml/kg body mass).In the second phase, mice were randomly divided into two groups:high-dose LH group (35.08 ml/kg body mass) and control group (dw 35.08 ml/kg body mass).After four weeks, a forced swimming test was performed and the biochemical parameters related to fatigue were examined .Results and Conclusion The administration groups showed a significant increase of swimming time to exhaustion compared with the control group , especially the high-dose group ( P<0.001).There was no significant change in the blood lactate between the two groups , but at 20 min after swimming, the lactic acid(LA) contents of the high-dose group were lower than in the control group (P>0.05).LH could significantly increase the liver glycogen contents and decrease the serum contents (P<0.05).These data indicate that LH has anti-fatigue activity and can elevate the exercise tolerance in mice . |
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Keywords: | fermented grain-containing blueberry anthocyanins anti-fatigue mice |
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