阿那曲唑的合成工艺改进

通过相转移催化反应合成阿那曲唑采用a，a，a'，a'，5-五甲基-1，3-苯二乙腈为起始原料，在溴化剂N-溴代丁二酰亚胺作用下溴化生成中间体3，5-二（2，2-二甲基）氰基甲基]-溴甲基苯，所得溴代中间体进而与1，2，4-三氮唑在水及有机溶剂中采用相转移催化缩合生产阿那曲唑。总收率达75%。

An Improved Synthesis Process for Anastrozole

This is a method for the synthesis of anastrozole using phase transfer catalyst: the bromination reaction of a,a,a',a',5-pentamethyl-1,3-benzenediacetonitrile as the starting material with N-bromosuccinimide as the bromide reagent give the intermediate 3,5-bis (2,2-dimethyl)-cyanic methyl]-bromo methyl bengene; then the intermediate was reacted with 1,2,4- triazole in water and organic solvents by phase transfer catalytic condensation to obtain anastrozole. The total yield was up to 75%.