| HLA-DQA1*0301及*0103与腔隙性脑梗死和原发性高血压的遗传易感性研究 |
| |
| 引用本文： | 沈乃莹,闫征,何培英,金宇安,王申五. HLA-DQA1*0301及*0103与腔隙性脑梗死和原发性高血压的遗传易感性研究[J]. 中华微生物学和免疫学杂志, 2001, 21(5): 497-500 |
| |
| 作者姓名： | 沈乃莹 闫征 何培英 金宇安 王申五 |
| |
| 作者单位： | 1. 北京中医药大学附属护国寺中医医院内科教研组
2. 北京大学人民医院中心实验室 |
| |
| 摘 要： | 目的：针对腔隙性脑梗死（lacunar stroke,LS）和原发性高血压（essential hypertension,EH)及多基因致病特点，进行HLA－DQA1位点的基因分型，分析其遗传易感性。方法：采用PCR－SSP方法对62例LS、52例EH和64例正常对照进行HLA－DQA1位点的基因分型。结果：①HLA－DQA1*0301等位基因与LS及EH呈显著正相关。②HLA－DQA1＊0103等位基因与LS及EH呈显著负相关。结论：HLA－DQA1*0301等位基因与LS及EH的发病有一定的关联，而HLA－DQA1＊0103等位基因可能是LS及EH的保护性基因。
|
| 关 键 词： | 腔隙性脑梗死 高血压 遗传易感性 人类白细胞抗原－DQA1 |
| 修稿时间： | 2000-09-11 |
A study of HLA-DQA1*0301 and *0103 hereditary susceptibility between lacunar stroke and essential hypertension |
| |
| SHEN Naiying ,YAN Zheng,HE Peiying,et al.. A study of HLA-DQA1*0301 and *0103 hereditary susceptibility between lacunar stroke and essential hypertension[J]. Chinese Journal of Microbiology and Immunology, 2001, 21(5): 497-500 |
| |
| Authors: | SHEN Naiying YAN Zheng HE Peiying et al. |
| |
| Affiliation: | SHEN Naiying *,YAN Zheng,HE Peiying,et al. *Department of Internal Medicine,Hu Guo Si Hospital of Traditional Medicine Affliated to Beijing Traditional Medicine and Herbs University,Beijing 100035,P. R. China |
| |
| Abstract: | Objective To analyze the hereditary susceptibility by genotyping of HLA DQA1 alleles according to trait of multiple genes leading to diseases in lacunar stroke(LS)and essential hypertension (EH). Methods The allelic typing of HLA DQA1 was done by PCR SSP in 62 cases of LS,52 cases of EH and 64 cases of normal individuals. Results The frequency of HLA DQA1*0301 was obviously higher in groups of LS and EH patients, and the frequency of HLA DQA1*0103 was significantly lower in LS and EH patients. Conclusion HLA DQA1*0301 allele might be a correlative gene with hereditary susceptibility of LS and EH, whereas HLA DQA1*0103 allele might be a protective gene in the patients with LS and EH. |
| |
| Keywords: | Lacunar stroke Hypertension Hereditary susceptibility HLA DQA1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
