| IGF—Ⅰ,IGF—Ⅱ及其受体在肝癌和癌旁肝组织中的表达 |
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| 引用本文： | 范子荣 杨冬华. IGF—Ⅰ,IGF—Ⅱ及其受体在肝癌和癌旁肝组织中的表达[J]. 癌症, 2000, 19(2): 150-152,155 |
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| 作者姓名： | 范子荣 杨冬华 |
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| 作者单位： | 第一军医大学珠江医院消化科!广东广州510282 |
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| 基金项目： | 中国科学院资助项目，39470774， |
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| 摘 要： | 目的：探讨胰岛素样生长因子Ⅰ、Ⅱ及其受体在肝癌和癌旁肝组织中的表达其意义。方法：采用ＤＮＡ－ＲＮＡ原位杂交方法检测肝癌和癌旁肝中ＩＧＦ－Ⅰ、ＩＧＦ－Ⅱ及其本 ｍＲＮＡ的表达。结果：在肝癌组织中ＩＧＦ－Ⅰ、ＩＧＦ－Ⅰ受体、ＩＧＦ－Ⅱ、ＩＧＦ－Ⅱ受体ｍＲＮＡ的表达率分别为４０．０％、４６．７％、６６．７％和６３．３％，在癌旁肝组织中ＩＧＦ－Ⅰ、ＩＧＦ－Ⅰ受体，ＩＧＦ－Ⅱ、ＩＧＦ－Ⅱ受体ｍＲＮＡ的表达率
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| 关 键 词： | 肝细胞癌 IGF－Ⅰ IGF－Ⅰ受体 IGF－Ⅱ IGF－Ⅱ受体 |
Expressions of IGF-I, IGF-II and their receptor mRNAs in hepatocellular carcinomas and adjacent non tumor tissues |
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| FAN Zi rong,YANG Dong hua,QIN Han rong,et al.. Expressions of IGF-I, IGF-II and their receptor mRNAs in hepatocellular carcinomas and adjacent non tumor tissues[J]. Chinese journal of cancer, 2000, 19(2): 150-152,155 |
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| Authors: | FAN Zi rong YANG Dong hua QIN Han rong et al. |
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| Affiliation: | FAN Zi rong,YANG Dong hua,QIN Han rong,et al. Department of Gastroenterology,Zhujiang Hospital,The First Military Medical University,Guangzhou 510282,P.R. China |
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| Abstract: | Objective: To clarify the clinical significance and effect of the expression of IGF I,IGF II and their receptors in hepatocellular carcinomas (HCC) and adjacent non tumor tissues. Method: In situ hybridization was used to detect the mRNAs for IGF I,IGF II and their receptors in HCC and adjacent non tumor tissues. Results:The expressions of IGF I, IGF IR, IGF II, and IGF IIR mRNA were detected in 40.0%, 46.7%, 66.7%and 63.3%, respectirely in HCC. Positive hybridization signals of IGF I, IGF IR, IGF II, and IGF IIR mRNA were found in 46.7%, 53.3%, 70.0% , and 73.3%of adjacent non tumor tissues.The liver cell dysplasia and poorly differentiated HCC cells were stained strongly positive. Conclusion:Coordinate overexpression of IGF I, IGF II and their receptors might play an important role in the formation and development of HCC. |
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| Keywords: | Hepatoma IGF I IGF I receptor IGF II IGF II receptor In situ hybridization |
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