美托洛尔对充血性心力衰竭患者心室重塑和心功能的影响

目的　观察美托洛尔对充血性心力衰竭 (CHF)患者心室重塑和心功能的影响。方法　 6 6例CHF患者均接受基础治疗 (洋地黄、利尿剂、血管紧张素转换酶抑制剂 ) ,并随机分为治疗组和对照组 ,治疗组加用美托洛尔治疗 6个月后观察其对心室重塑及心功能的变化。应用心脏彩色超声仪测定两组治疗前及治疗后 1个月、3个月、6个月左室结构及功能指标变化。结果　治疗 6个月后 ,治疗组症状和心功能明显改善 (P <0 0 1) ,左室射血分数 (LVEF)明显升高 (P <0 0 1)。结论　在强心、利尿、ACEI基础上 ,长期应用美托洛尔能显著改善CHF患者心室重塑和心功能。

The effect of metoprolol on the left ventricular remodeling and cardiac function in patients with congestive heart failure

Objective To study cardiac function improvement and remodeling process with metoprolol therapy in patients with congestive heart failure.Methods 66 patients received basline therapy (digitalis,diuretic andACEI) were randomlyinto to control group and treatment group for a 6-month follow-up period.In the treatment group metoprolol was given.The data of ventricular function were measured by 20-echocardiography at baseline, 1,3 and 6 months after admission.Results In treatment group symptom scores and NYHA class improved(P<0.01),as reflected by the increased left ventricular ejection fraction(LVEF)(P<0.01).Conclusion Based on the medication of digitalis,diuretics and ACEI,metoprolol therapy can improve left ventricular performance,reverse LV remodeling in patients with cardiac dysfunction.