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Platelet monoamine oxidase and erythrocyte Catechol-o-Methyltransferase activity in alcoholism and controlled abstinence |
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| Authors: | O.P. Agarwal G. Philippu U. Milech B. Ziemsen O. Schrappe H.W. Goedde |
| Affiliation: | 1. Institut für Humangenetik der Universität Hamburg F.R.G.;2. Psychiatrische Klinik und Poliklinik in der Universität s-Nervenklinik Würzburg F.R.G. |
| Abstract: | This study substantiates previous reports that low platelet monoamine oxidase (MAO) activity is associated with alcoholism. Catechol-o-methyltransferase (COMT) activity in erythrocytes of alcoholics did not differ from that of controls. In 20 male alcoholics low platelet MAO activity was found during the first 3 days after hospitalization. The MAO activity increased in the next 2 weeks of abstinence and then tended to decrease again. |
| Keywords: | Alcoholism Platelet monoamine oxidase DBA, 3,4-dihydroxybenzoic acid HMBA, hydroxyethoxybenzoic acid MAO, monoamine oxidase |
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