| CCN家族研究进展 |
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| 引用本文： | 苏炳银 蔡文琴. CCN家族研究进展[J]. 第一军医大学学报, 2002, 22(2): 179-183 |
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| 作者姓名： | 苏炳银 蔡文琴 |
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| 摘 要： | 新近发现的CCN基因家族包括CTGF，Cyr61,nov,elml,HICP和WISP-3等，它们由343-381个氨基酸残基构成4个结构模块，都含有38个保守的半胱氨酸，具有广泛的生物学特性，影响细胞的生长，分化，粘附和运动，在妊娠，发育和分化，血管生成，伤口修复，炎性作用，肿瘤生长等多种生物学过程中起重要作用。
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| 关 键 词： | CCN家族 蛋白结构 生物学功能 |
Progress in the study of CCN family] |
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| Bing-Yin Su,Wen-Qin Cai. Progress in the study of CCN family][J]. Journal of First Military Medical University, 2002, 22(2): 179-183 |
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| Authors: | Bing-Yin Su Wen-Qin Cai |
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| Affiliation: | Department of Histology and Embryology, Third Military Medical University, Chongqing 400038, China. subingyin@yahoo.com.cn |
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| Abstract: | The last 5-6 years have seen the emergence of a new gene family that currently comprises CTGF, Cyr61, nov, elm1, HICP and WISP-3. The translational products of most CCN family members are secreted proteins that contain 343 to 381 amino-acid residues to compose 4 distinct structural modules, each having 38 conserved cysteine residues. These proteins have a variety of properties to affect the cellular behaviors such as growth, differentiation, adhesion and locomotion. They may play important roles in pregnancy, development and differentiation, angiogenesis, wound repair, fibrotic disorders, inflammation and tumor genesis. |
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