| 胞磷胆碱钠胶囊和吡拉西坦片治疗脑梗死比较 |
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| 引用本文： | 张丽莉,李红英,李义召.胞磷胆碱钠胶囊和吡拉西坦片治疗脑梗死比较[J].中国新药与临床杂志,2002,21(4):202-204. |
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| 作者姓名： | 张丽莉 李红英 李义召 |
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| 作者单位： | 1. 齐鲁制药厂,山东,济南,250100
2. 山东医科大学附属医院,神经内科,山东,济南,250010 |
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| 摘 要： | 目的 :比较胞磷胆碱钠胶囊和吡拉西坦片治疗脑梗死的疗效和不良反应。方法 :随机双盲双模拟对照试验。试验组 10 5例 (男性 5 5例 ,女性 5 0例 ,年龄 61a±s 12a)。每日口服胞磷胆碱钠胶囊9粒 (90 0mg)和安慰剂片 ,分 3次口服 ,8wk为一个疗程。对照组 10 5例 (男性 4 6例 ,女性 5 9例 ,年龄 60a± 9a) ,每日口服吡拉西坦片 6片 (2 4 0 0mg)和安慰剂胶囊 ,分 3次口服 ,8wk为一个疗程。结果 :试验组与对照组总有效率分别为 93.3% ,71.4 % ,2组比较差异有显著意义 (P <0 .0 5 )。结论 :胞磷胆碱钠胶囊是一个安全有效的治疗脑梗死药物 ,疗效优于吡拉西坦片。
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| 关 键 词： | 胞磷胆碱 脑梗死 双盲法 随机对照试验 |
| 文章编号： | 1007-7669(2002)04-0202-03 |
| 修稿时间： | 2000年9月11日 |
Citicoline capsules vs piracetam tablets in treatment of cerebral infarction |
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| Abstract: | AIM: To compare the clinical efficacy and adverse reaction of citicoline capsules and piracetam tablets in treating cerebral infarction. METHODS: The double blind and random method was used. In experimental group one hundred and five patients (M 55, F 50; age 61 a± s 12 a) were treated with three capsules of citicoline (0.1 g·capsule -1 ) and two tablets placebo po , tid for 8 wk. In control group one hundred and five patients (M 46, F 59; age 60 a±9 a) were treated with three capsules of placebo and two tablets of piracetam (0.4 g·tab -1 ), po , tid for 8 wk. RESULTS: The total effective rate was 93.3 % in the experimental group and 71.4% in the control group ( P <0.05). CONCLUSION: Citicoline capsules are superior to piracetam tablet in treating cerebral infarction. |
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| Keywords: | citicoline cerebral infarction double blind method randomized controlled trials |
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