| 免疫毒素的抗肿瘤研究及其改善策略 |
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| 引用本文： | 徐伟. 免疫毒素的抗肿瘤研究及其改善策略[J]. 国际肿瘤学杂志, 2010, 37(6). DOI: 10.3760/cma.j.issn.1673-422X.2010.06.006 |
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| 作者姓名： | 徐伟 |
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| 作者单位： | 南京医科大学第二附属医院消化内科,210029 |
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| 基金项目： | 江苏省自然科学基金资助项目 |
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| 摘 要： | 免疫毒素由特异性的单克隆抗体或生长因子与具有杀伤作用的毒素分子通过化学交联构建而成.它通过抑制癌细胞的蛋白合成或促进癌细胞凋亡发挥抗癌作用.与其他抗肿瘤药物相比,具有毒性强和特异性高的优点,在肿瘤治疗中显示出巨大的应用前景.但进入临床应用还存在很多限制性因素.
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| 关 键 词： | 免疫毒素 肿瘤 治疗 |
Anti-cancer effects of immunotoxins and its improvement strategy |
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| XU Wei. Anti-cancer effects of immunotoxins and its improvement strategy[J]. Journal of International Oncology, 2010, 37(6). DOI: 10.3760/cma.j.issn.1673-422X.2010.06.006 |
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| Authors: | XU Wei |
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| Abstract: | Immunotoxin is composed of chemical crosslinked mixture of specific monoclonal antibody or growth factor and toxin. Immunotoxin exerts its anti-cancer effects through inhibiting protein synthesis in cancer cells and promoting cancer cell apoptosis. Although immunotoxin is characterized by high toxicity and specificity which may provide remarkable potential in tumor therapy compared with traditional anti-cancer drugs, there are a lot of limitations for its clinical application. |
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| Keywords: | Immunotoxins Neoplasms Therapy |
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