Feasibility of arterial spin labeling on a 1T open MRI scanner |
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Authors: | Dennis FR Heijtel MSc Matthias JP van Osch PhD Matthan WA Caan PhD Charles B Majoie MD PhD Ed vanBavel PhD Aart J Nederveen PhD |
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Institution: | 1. Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands;2. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands;3. Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands |
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Abstract: | Purpose: To determine the clinical feasibility of arterial spin labeling (ASL) on a 1T open bore scanner. Materials and Methods: First, the optimal postlabeling delay (PLD) at 1T was determined (n = 5), with and without vascular crushing. Second, the effect of different labeling approaches (pseudo‐continuous ASL pCASL] vs. pulsed ASL PASL]), background suppression (BSup) and readout options (GRASE vs. EPI) was investigated (n = 9). Each effect was quantified by calculating the signal‐to‐noise ratio (SNR), convergence, and number of significant gray matter (GM) voxels in the ASL images. Finally, an example of an obese volunteer who could not have been scanned in a cylindrical scanner is presented. Results: The optimal PLDs were found to be 1300 msec for pCASL with and without vascular crushing. pCASL labeling outperformed PASL labeling in terms of convergence, anatomical correspondence between GM and perfusion maps, and SNR (P < 0.05). BSup appeared to have no additional value on the convergence, anatomical GM correspondence, and SNR (P > 0.05). EPI readout yielded a slightly better convergence, while the SNR of the GRASE readout was higher (P < 0.05). Conclusion: ASL on 1T is clinically feasible using state‐of‐the‐art sequences that were primarily developed for higher field strengths. J. Magn. Reson. Imaging 2013;37:958–964. © 2012 Wiley Periodicals, Inc. |
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Keywords: | arterial spin labeling cerebral blood flow perfusion MRI open bore |
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