Diffusion tensor imaging of Parkinson's disease,atypical parkinsonism,and essential tremor |
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| Authors: | Janey Prodoehl PhD Hong Li PhD Peggy J. Planetta PhD Christopher G. Goetz MD Kathleen M. Shannon MD Ruth Tangonan Cynthia L. Comella MD Tanya Simuni MD Xiaohong Joe Zhou PhD Sue Leurgans PhD Daniel M. Corcos PhD David E. Vaillancourt PhD |
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| Affiliation: | 1. Physical Therapy Program, Midwestern University, , Downers Grove, Illinois, USA;2. Department of Preventive Medicine, Rush University Medical Center, , Chicago, Illinois, USA;3. Department of Applied Physiology and Kinesiology, University of Florida, , Gainesville, Florida, USA;4. Department of Neurological Sciences, Rush University Medical Center, , Chicago, Illinois, USA;5. Department of Kinesiology and Nutrition, University of Illinois at Chicago, , Chicago, Illinois, USA;6. Parkinson's Disease and Movement Disorders Center, Northwestern University, , Chicago, Illinois, USA;7. Department of Radiology, University of Illinois at Chicago, , Chicago, Illinois, USA;8. Department of Bioengineering, University of Illinois at Chicago, , Chicago, Illinois, USA;9. Center for MR Research, University of Illinois at Chicago, , Chicago, Illinois, USA;10. Rush Alzheimer's Disease Center, Rush University Medical Center, , Chicago, Illinois, USA;11. Department of Psychology, University of Illinois at Chicago, , Chicago, Illinois, USA;12. Department of Neurology, University of Florida, , Gainesville, Florida, USA;13. Department of Biomedical Engineering, University of Florida, , Gainesville, Florida, USA |
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| Abstract: | Diffusion tensor imaging could be useful in characterizing movement disorders because it noninvasively examines multiple brain regions simultaneously. We report a multitarget imaging approach focused on the basal ganglia and cerebellum in Parkinson's disease, parkinsonian variant of multiple system atrophy, progressive supranuclear palsy, and essential tremor and in healthy controls. Seventy‐two subjects were studied with a diffusion tensor imaging protocol at 3 Tesla. Receiver operating characteristic analysis was performed to directly compare groups. Sensitivity and specificity values were quantified for control versus movement disorder (92% sensitivity, 88% specificity), control versus parkinsonism (93% sensitivity, 91% specificity), Parkinson's disease versus atypical parkinsonism (90% sensitivity, 100% specificity), Parkinson's disease versus multiple system atrophy (94% sensitivity, 100% specificity), Parkinson's disease versus progressive supranuclear palsy (87% sensitivity, 100% specificity), multiple system atrophy versus progressive supranuclear palsy (90% sensitivity, 100% specificity), and Parkinson's disease versus essential tremor (92% sensitivity, 87% specificity). The brain targets varied for each comparison, but the substantia nigra, putamen, caudate, and middle cerebellar peduncle were the most frequently selected brain regions across classifications. These results indicate that using diffusion tensor imaging of the basal ganglia and cerebellum accurately classifies subjects diagnosed with Parkinson's disease, atypical parkinsonism, and essential tremor and clearly distinguishes them from control subjects. © 2013 International Parkinson and Movement Disorder Society |
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| Keywords: | DTI parkinsonism essential tremor basal ganglia cerebellum |
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