Preliminary studies of a novel cyclopentadienyl tricarbonyl technetium‐99m fatty acid derivative for myocardical imaging |
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| Authors: | Huahui Zeng Huabei Zhang Xiangxiang Wu Fangfang Chao Gang Yu Liqing Zhang Han Jiang Hongbiao Liu Haifeng Hou Hongwei Zhan Hong Zhang Mei Tian |
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| Affiliation: | 1. Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, , Hangzhou, China, 310009;2. Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, , Beijing, China, 100875;3. Pharmacy College, Henan University of Traditional Chinese Medicine, , Zhengzhou, China, 450008 |
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| Abstract: | This study reports the synthesis and evaluation studies of 6′‐cyclopentadienyl tricarbonyl technetium‐99m 6′‐oxo‐11‐(hexanamide)undecanoic acid (1). 1 was prepared with 26.5 ± 4.3% of radiochemical yield and more than 98% of radiochemical purity. Tissue distribution in mice showed that high radioactivity accumulated in the heart with moderate clearance. However, unfortunately, similar to those of other technetium‐labeled fatty acid analogs, the biodistribution studies of 1 in mice showed poor heart‐to‐blood ratios, which suggested that 1 cannot be used as myocardial imaging agent, and it may provide a theoretical basis or a lab experience for corresponding fatty acid tracers studies. |
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| Keywords: | fatty acid technetium‐99m tissue distribution myocardium |
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