Reproducibility and biological basis of in vivo T2* magnetic resonance imaging of liver metastasis of colorectal cancer |
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| Authors: | E. G. W. ter Voert L. Heijmen J. H. W. de Wilt J. Bussink C. J. A. Punt H. W. M. van Laarhoven A. Heerschap |
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| Affiliation: | 1. Department of Radiology, Radboud University Nijmegen Medical Centre, , Nijmegen, The Netherlands;2. Department of Medical Oncology, Radboud University Nijmegen Medical Centre, , Nijmegen, The Netherlands;3. Department of Surgery, Radboud University Nijmegen Medical Centre, , Nijmegen, The Netherlands;4. Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, , Nijmegen, The Netherlands;5. Department of Medical Oncology,Academic Medical Centre, University of Amsterdam, , Amsterdam, The Netherlands |
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| Abstract: | In this study, the reproducibility of  MR imaging in colorectal liver metastases was assessed and  values were correlated with the expression of the hypoxia‐related markers GLUT‐1 and CA‐IX as well as the relative vascular area, and the vessel density in resected tumors. The reproducibility of  was analyzed in 18 patients with in total 22 colorectal liver metastases using the Bland and Altman method for the 16th, 50th, and 84th percentile values. Immunohistochemical staining was performed on 17 resected tumors obtained from 16 patients. The median  of all liver metastases was 25.0 ± 5.6 ms vs. 23.0 ± 4.1 ms (median ± st.dev.) in normal liver. The coefficient of repeatability was 11.2 ms and the limits of agreement were ?13.2 ms and 9.1 ms for median  values. On average,  showed fair reproducibility. No correlations between  values, hypoxia‐ and vascularity‐related markers were observed. Magn Reson Med, 70:1145–1152, 2013. © 2012 Wiley Periodicals, Inc. |
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| Keywords: | MR liver tumor histopathology hypoxia metastasis colorectal cancer in vivo |
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