Effectiveness of a community-based intervention for weight loss on cardiometabolic risk factors among overweight and obese women in a low socio-economic urban community: findings of the MyBFF@home |
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Authors: | Ahmad Zamri Liyana Geeta Appannah Siti Yazmin Zahari Sham Mansor Fazliana Noor Safiza Mohamad Nor Rashidah Ambak Azah Abdul Samad Nofi Yuliani Dahlan Tahir Aris |
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Affiliation: | 1.Cardiovascular, Diabetes and Nutrition Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia,Kuala Lumpur,Malaysia;2.Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences,Universiti Putra Malaysia,Serdang,Malaysia;3.Department of Pathology, Faculty of Medicine and Health Sciences,Universiti Putra Malaysia,Serdang,Malaysia;4.Institute for Public Health, National Institutes of Health, Ministry of Health Malaysia,Kuala Lumpur,Malaysia;5.Shah Alam Seksyen 7 Health Clinic, Persiaran Kayangan,Shah Alam,Malaysia;6.Occupational Safety & Health Unit, Gombak District of Health Office,Batu Caves,Malaysia |
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Abstract: | BackgroundThe effectiveness of lifestyle intervention for weight loss on cardiometabolic risk factors among overweight and obese individuals in the community setting remains inconclusive. This study aimed to evaluate the effect of a 6-month weight loss lifestyle intervention on cardiometabolic risk factors among overweight and obese women and the sustainability of the changes in those markers at 12-month follow-up, comparing an intervention group with a control group.MethodsA total of 243 participants from MyBFF@home were included in this study. Fasting blood samples at baseline, 6- and 12-month were assessed for fasting plasma glucose (FPG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides. The effect of the intervention on cardiometabolic risk markers were investigated within and between study groups using t-test and general linear model (GLM) repeated measure ANOVA.ResultsResults from repeated measures ANOVA showed intervention effect only in TC where significant reduction was found in the intervention group (? 0.26 mmol/L [95% CI: – 0.47 to ? 0.06], p?0.01) compared to the control group (? 0.06 mmol/L [95% CI: – 0.28 to 0.17]) at 12 months. At 6 months, TC was reduced significantly in both groups but only intervention group retained the reduction in maintenance phase while, the level increased significantly in the control group (0.22 mmol/L [95% CI: 0.06 to 0.38]). This attributed to significant increase in TC/HDL-C ratio in the control group during maintenance phase (0.32 [95% CI: 0.15 to 0.50], p?0.001). The intervention group also showed trend of reduction in FPG at 6 months and further decreased during maintenance phase (??0.19 mmol/L [95% CI: – 0.32 to ? 0.06], p?0.01). At 6 months HDL-C was maintained in the intervention group but reduced significantly in the control group (??0.05 mmol/L [95% CI: – 0.10 to ? 0.01], p?0.05). No significant difference was detected in both markers when compared between groups.ConclusionsIn the context of low socio-economic communities, this study supports that weight loss related lifestyle modifications over a 6-month period could improve selected cardiometabolic risk factors, particularly fasting glucose, TC and HDL-C in overweight and obese women with favourable sustainability over a 12-month period. |
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