Diffusion‐weighted imaging of the healthy pancreas: ADC values are age and gender dependent |
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Authors: | Jochen Herrmann MD Bjoern P. Schoennagel MD Magdalena Roesch MD Jasmin D. Busch MD Thorsten Derlin MD Laura K. Doh MD Kay U. Petersen PhD Joachim Graessner MS Gerhard Adam MD Christian R. Habermann MD |
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Affiliation: | 1. Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg‐Eppendorf, Hamburg, Germany;2. Section for Addiction Research and Therapy, University Department for Psychiatry and Psychotherapy, Tübingen, Germany;3. Siemens AG Healthcare, Hamburg, Germany |
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Abstract: | Purpose: To investigate the healthy pancreas with diffusion‐weighted imaging (DWI) for characterization of age and gender‐related differences in apparent diffusion coefficient (ADC) values. Materials and Methods: Sixty six volunteers were prospectively enrolled (33 male, 33 female; range 1.4 to 83.7 years of age) and echo‐planar DWI of the pancreas was performed. ADC values were measured in the pancreas head, body, and tail using a pixel‐by‐pixel approach. Effects of age and gender on ADC values were analyzed using a two‐factorial multivariate analysis of variance (MANOVA). Results: ADC values correlated inversely with the age of the volunteers. The mean global pancreatic ADC values (× 10?3 mm2/s) in the age groups 0–20 years, 21–40 years, and > 40 years were 1.18 ± 0.19, 1.07 ± 0.13, and 0.99 ± 0.18, respectively. Female individuals had higher mean global ADC values than male (1.13 ± 0.14 versus 1.02 ± 0.18 × 10?3 mm2/s). MANOVA showed significant effects of age (P value 0.022, eta2 = 0.13) and gender (P value 0.001, eta2 = 0.28) on ADC values. Conclusion: Pancreatic ADC values decline with ageing and show significant gender differences with higher mean values in females. The awareness of baseline values adjusted to age and gender will be important for correct interpretation of individual cases and design of future studies. J. Magn. Reson. Imaging 2013;37:886–891. © 2012 Wiley Periodicals, Inc. |
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Keywords: | pancreas MRI diffusion‐weighted imaging apparent diffusion coefficient age gender |
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