1. Chengdu Institute of Organic Chemistry, Chinese Academy of Science, Center of Polymer Science and Technology, , Chengdu, 610041 People's Republic of China;2. University of Chinese Academy of Sciences, , Beijing, 100049 People's Republic of China;3. National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, , Chengdu, 610065 People's Republic of China;4. Key Laboratory of Leather Chemistry and Engineering (Sichuan University), Ministry of Education, , Chengdu, 610065 People's Republic of China
Abstract:
Linear amphiphilic triblock polymers containing a single diselenide (SeSe‐tri‐ABP) are synthesized by coupling reactions. They self‐assemble into spherical micelles 1 in aqueous solution. A remarkable morphology transformation of the micelles is confirmed through dynamic light scattering (DLS) and transmission electron microscopy (TEM). The release behavior of a model molecule, Rhodamine B (RB), is studied by UV–vis spectrophotometry. It is found that post‐assembly from micelles 1 to micelles 2 is induced by the oxidation‐responsive cleavage of the diselenide group in the oxidation solution. Interestingly, the RB release studies reveal that these micelles release RB in a diphasic pattern (slow after initial fast release) within 24 h under an oxidative environment. In contrast, minimal drug release (<20%) is observed within 24 h for SeSe‐tri‐ABP micelles under aqueous conditions. Meanwhile, this release behavior of the RB‐loaded micelles can be tuned by the post‐assembly of oxidation‐responsive SeSe‐tri‐ABP in different oxidation conditions, providing a promising platform for controlled delivery of nanocarriers.
